The Human Operating Manual

The Road to Sapiens

The Road to Sapiens Anthropology and human history https://www.southampton.ac.uk/~cpd/history.html?utm_campaign=mb&utm_medium=newsletter&utm_source=morning_brew Theories on the birth of human “intelligence” The passing of experience through language to create group knowledge. The structure of a journey represents to process of venturing out into new territory, overcoming an obstacle, and returning with new information or reward. Stories these days add failure …

Evolution & Genetics

Evolution & Genetics Sapolsky: Sexual selection and reproductive fitness Kinship and degree of relatedness Reciprocal altruism. Must be smart enough to remember each other and their interactions. Must be long lived. Cooperation, cheating, detecting cheating. Caveat: bacteria still do tit for tat and reciprocal interaction.  Game theory. Prisoner’s dilemma Optimizing genetics for the given environment. …

LUCA & the Energy Bubbles

LUCA & the Energy Bubbles Potential hypotheses for life: thermal vents, spark (lightening), panspermia, etc. What life means: Encapsulated potential for energy that is used for greater dispersal Sponges and mat grazers (Mike Paulin research). Fear vs gain (glutamate and calcium channels) Bayesian Brain Theory, The Free Energy Principle https://www.nature.com/articles/nrn2787 https://medium.com/@solopchuk/intuitions-on-predictive-coding-and-the-free-energy-principle-3fc5bcedc754 Our senses, epithelial cells, …

Energy Factories

Energy Factories Mitochondria http://thehumanoperatingmanual.com/mitochondria-and-the-future-of-medicine-the-key-to-understanding-disease-chronic-illness-aging-and-life-itself/ Mineral Fix notes Minerals Driving Energy Production In total, there are up to 22 vitamins and minerals that support mitochondrial enzymes and are needed for energy production. Minerals also help to activate antioxidant enzymes that protect the mitochondria from oxidative stress. Deficiencies in these minerals can lead to a reduction in …

Emergence & Complexity

Emergence & Complexity https://quantumgravityresearch.org/emergence-theory-overview/ https://en.wikipedia.org/wiki/Free_energy_principlehttps://en.wikipedia.org/wiki/Integrated_information_theoryhttps:// www.frontiersin.org/articles/10.3389/fpsyg.2020.01041/fullhttps://pubmed.ncbi.nlm.nih.gov/29729890/ https://www.sciencedirect.com/science/article/abs/pii/S027322972100054X

Entropy

Entropy https://pubmed.ncbi.nlm.nih.gov/34385400/ Connection between the universal demonstration of entropy and our micro example. Our role as an entropy accelerator rather than a resistor. Complexity theory, feedback loops, Jeremy England theory, mitochondrial synergy.  Once we have an averaged energy systems model to detect dysfunction/metabolic leakage, we should be able to use computational neuroscience to replicate and …

Lifespan: Why We Age and Why We Don’t Have To

Lifespan: Why We Age and Why We Don’t Have To Author: David Sinclair Topics: Longevity, cancer All information is attributed to the author. Except in the case where we may have misunderstood a concept and summarized incorrectly. These notes are only for reference and we always suggest reading from the original source. Contents Part I: …

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