Contents

Part I: Don’t Die

1. The Four Killers

2. The Seven Pillars of Aging

3. Food Is an Anti-Aging Drug

4. Sleep or Die

5. Using Light to Gain Super Powers

Part II: Age Backward

6. Turn Your Brain Back On

7. Metal Bashing

8. Polluting Your Body with Ozone

9. Fertility = Longevity

10. You Teeth Are a Window to the Nervous System

11. Humans Are Walking Petri Dishes

Part III: Heal Like a Deity

12. Virgin Cells and Vampire Blood

13. Don’t Look Like an Alien: Avoiding Baldness, Grays, And Wrinkles

14. Hack Your Longevity Like a Russian

Part I: Don’t Die

1. The Four Killers

As mitochondrial function declines, they start to produce excess free radicals, which damages themselves and surrounding cells. Vitamin C is sent to the liver to produce antioxidants, leaving little vitamin C for building collagen. Vitamin C interacts with amino acids to build collagen for bones, skin, teeth, cartilage, and organs. Resulting in stretch marks, vascular issues, and joint problems if you don’t produce enough. Not to mention mitochondrial decline leading to prediabetes, poor blood flow to the brain, arthritis, cognitive dysfunction, and higher risk of stroke and heart attack.

Heart Disease

When the endothelial lining of the arteries is damaged, fats can cross into the arterial wall and form plaques. Inflammatory cytokines are then released to attract WBCs. When the plaques rupture, they can cause clots. The fat molecules that cause plaque apparently come from bad gut bacteria rather than the diet (what do the bad gut bacteria eat though?). Suggesting a diet high in resistant starches may allow good bacteria to produce short-chain, anti-inflammatory fatty acids. Could be caused by toxic mold exposure (causing postural orthostatic tachycardia syndrome). Inflammation can also disrupt the communication between the nervous system and the endocrine system, leading to fatigue and blood pressure instability, and ADHD and Asperger’s symptoms.

Diabetes

During diabetes, macrophages can release inflammatory cytokines into otherwise healthy cells, causing nearby cells to become insulin resistant. Excess blood sugar causes damage to the entire vasculature, increasing heart disease and stroke risk. High blood sugar also causes nerve damage by damaging capillaries (peripheral artery disease). Diabetes can also damage your kidneys, affecting filtration, resulting in kidney disease. Not to mention the massive increased risk of Alzheimer’s with diabetes. Macrophages can also trigger inflammation in adipose tissue.

Moderate muscle strength has been shown to lower the risk of diabetes by 32% compared to those with low muscle strength. No major change with greater muscle.

Glucosamine inhibits glycolysis, resulting in the body requiring energy from fat stores instead of glucose. It has also been shown to mimic calorie restriction and extend life-span.

Alzheimer’s

Microglia release cytokines in response to threat, triggering inflammation. Chronic inflammation can result in neuronal damage.

Cancer

When mitochondria become dysfunctional and don’t produce energy efficiently, risk of cancer goes up. An inflamed environment is perfect for cancer growth. When the body is injured, cells proliferate quickly to heal the wound. With excess free radicals around, DNA can be damaged, developing mutated cells.

Only 2-5% of cancers are truly genetic. Mitochondrial dysfunction is responsible for most of the rest. Specifically anaerobic metabolism in the absence of oxygen.

Slash Your Risk

Between 30-70 years old you experience a decrease of up to 50% in mitochondria numbers. If you are “average”, you have a 23% risk of dying from heart disease, 25% risk of diabetes, 10% risk of Alzheimer’s, and 40% risk of cancer and 20% chance of dying from it.

Do these things now:

• If you have joint pain or blood sugar issues, take glucosamine
• Consume more antioxidants
• Short periods of fasting
• Zona Plus: digitally controlled handheld device that increases vascular flexibility and production and flow of nitric oxide

2. The Seven Pillars of Aging

Not ironclad evidence but compelling research to suggest the following.

Pillar 1 – Shrinking Tissues

As you age, stem cell reserves deplete and age, becoming less efficient. As well as mitochondria not triggering apoptosis at the right times. Keeping mitochondria healthy can reduce unnecessary cell loss.

Pillar 2 – Mitochondrial Mutations

Mitochondrial DNA has limited ability to repair itself and is therefore more likely to undergo mutation than human DNA. Mitochondria usually gets damaged during periods of chronic inflammation and increased ROS, resulting in inefficient energy production and production of more free radicals.

Pillar 3 – Zombie Cells

Death-resistant cells, aka senescent cells, are cells that won’t die when worn out. They won’t divide or function properly either. Releasing inflammatory proteins, causing chronic inflammation. Mitochondria in these cells become dysfunctional and release huge amounts of ROS (senescence associated mitochondrial dysfunction).

Zombie cells are a precursor to type 2 diabetes, increased visceral fat, and symptoms of aging like arthritis.

Keep cell membranes strong by consuming calcium, magnesium, and potassium salts of amino ethanol phosphate. Metformin is believed to kill senescent cells. Rapamycin inhibits a growth pathway called mammalian target of rapamycin (mTOR), which is responsible for regulating cell growth, cell death, proliferation, and autophagy. Inhibiting mTOR appears to prevent senescent cell growth. Fisetin is a polyphenol found in seaweed and strawberries that has been shown to kill up to 50% of senescent cells in a particular organ. Ashitaba has been used for high blood pressure, hay fever, gout, and digestive issues, but it also contains dimethoxychalcone, which slows cell senescence. Piperlongumine (PPL), used in Ayurvedic medicine. PPL may have cancer fighting benefits but needs more research and may load the liver too much (suggests taking glutathione to support the liver).

Pillar 4 – Cellular Straightjackets

Extracellular matrix stiffening results in the body needing to work harder to pump blood. When sugar in your blood permanently binds with proteins, creating inflammatory advanced glycation end products (AGEs). The most abundant AGE in collagen is glucosepane, which contributes to diseases of aging like diabetes and vascular dysfunction.

Chronic inflammation is also associated with an increase in cross-linked proteins. He recommends a Viome test to test for inflammation and excess AGEs.

Pillar 5 – Extracellular Junk

When waste products like amyloids start to accumulate, they stick together and form plaques, getting in the way of normal cellular function. Alzheimer’s is associated with beta-amyloid and type 2 diabetes is associated with islet amyloid inhibiting insulin secretion. Protein aggregates also cause a stiffening of the heart (senile cardiac amyloidosis).

Autoimmunity makes protein aggregation worse and so does low insulin levels in the brain (brain amyloid formation specifically). Reduce foods you are sensitive to and calm down to reduce inflammation and chronic stress. Vitamin D apparently helps to prevent protein malformation and sticking together.

Excess copper can be toxic and bind proteins, preventing clearance. Lead, arsenic, mercury, nickel, uranium, and cadmium exposure can impair mitochondrial energy production and cell death. Conflicting information to Morley Robbins’ “Root Cause Protocol”.

Pillar 6 – Junk Buildup Inside Cells

Lysosomes incinerate unwanted materials. When they can’t break products down, they sit there clogging up a cell until it can no longer function (intracellular aggregation). Resulting in loss of cells and tissue atrophy. This can happen if lysosomes are damaged , if they don’t have enough of the 60 types of enzymes required, or when exposed to excess ROS from dysfunctional mitochondria. AGEs can get stuck inside your cells, making cells more dysfunctional. Fried and charred foods contribute to these AGE levels.

Pillar 7 – Telomere Shortening

The number of times a cell can replicate before it is no longer protected by telomeres and dies is called the Hayflick limit. Shortened telomeres are linked to a weakened immune system and chronic and degenerative diseases like heart diseases and heart failure, diabetes, cancer, and osteoporosis.

Perceived levels of stress are correlated with telomere length. Feeling like you feel more stress leads to shorter length.

By middle age, telomeres are much longer in those that exercise. Which appears to be contributed to by reduced perceived stress levels and inflammation.

Epitalon (synthetic peptide) is modelled after epithalamin, which is produced by the pineal gland. It appears to turn on apoptosis and slow tumor growth.

TA-65 (cycloastragenol) also activates telomerase. It is a concentrated extract of astralagus.

Do these things:

• Kill off death resistant cells with compounds like AEP, fisetin, and piperlongumine
• Consider rapamycin or metformin from your doctor
• Stop eating fried, charred, and grilled meat
• Manage stress – meditate, yoga, good quality sleep, and/or delegate tasks that are draining you
• Vitamin D to prevent misshapen proteins
• Elimination diet to avoid incompatible foods

3. Food Is An Anti-Aging Drug

Grains, Gluten, Glucose, and Glyphosate (OH MY)

Wheat causes inflammation and gastrointestinal distress and contributes to autoimmunity and other issues by stimulating an over-release of zonulin (controls permeability of tight junctions in gut lining). Allowing bacteria, undigested food, and bacterial toxins into the bloodstream.

Gluten also reduces blood flow to the brain, interferes with thyroid function, and depletes your vitamin D stores. Resulting in misshapen proteins and aging plaque deposits.

Most crops and grains are now sprayed with glyphosate, a probable carcinogen. It also is potentially genotoxic (causes DNA mutations) and increases oxidative stress, triggering inflammation, and speeding up aging. Glyphosate also mimics estrogen and Roundup is directly toxic to mitochondria and human placental cells. Glyphosate is a glycine molecule attached to a methylphosphonyl group, which can get incorporated into your extracellular matric like glycine. Wrinkles, kidney damage (protein formation issues), cancer, hormonal disruption, etc. Meat and dairy may be raised on glyphosate covered grain.

The Vegan Trap

Omega-6 vegetable oils reduce thyroid function by preventing thyroid hormone from binding to receptors. At first, the thyroid hormone will temporarily increase to compensate for low energy, and you feel good. Because your cells won’t have essential building blocks to run efficiently, your metabolism slows, making weight gain easier, slowing the brain, energy, etc. 6 weeks of feeling great, due to a last ditch attempt from the body to find and catch prey, followed by the crash. However, excess protein can cause inflammation, due to amino acids like methionine causing inflammation (collagen has less). A U-shaped curve for protein.

Daily protein intake: Aim for 0.5g x pounds in lean muscle.

Turning amino acids from protein into energy creates more waste than fat or carbs, and excess protein ferments in the gut and produces ammonia and nitrogen, placing load on the liver and kidneys.

Eat enough protein for tissue and lean muscle repair, energy from fat and carbs, and fiber for bacteria to break down as fatty acids for mitochondria. By restricting protein occasionally, you force the body to recycle proteins and excrete waste products. This can be done by intermittently fasting too.

A Big Fat Leap Of Faith

Vitamins A, E, D, and K are fat soluble and hormones like leptin are made from saturated fat and cholesterol. Myelin is also made from fat. Saturated fat is so important that the body can convert carbs into palmitate, a type of saturated fat, which gets converted into other saturated fats and monosaturated fats necessary for cell membranes. Remember that it is gut bacteria that creates plaques that build up in arteries, not dietary cholesterol.

Your body converts carbohydrates into glucose, which mitochondria use for energy. When you run out, fat gets converted into glycerol for energy. The liver produces ketones as a by-product of fat metabolism, and your mitochondria burn ketones instead of glucose in a more efficient form of energy production.

The general rule of thumb is that the shorter the saturated fat the more anti-inflammatory it is, such as butyric acid. Oxidized fats cause you to age more quickly by building less effective cell membranes. Your cells use saturated fats, which are the most stable of the fats, to make about 45% of the cell membranes in the brain and liver, and 35% in the heart and muscle cells. When you eat more saturated fats, the cells in adipose tissue change their makeup to contain more stable saturated fats without changing in size. Resulting in fewer free radicals from unstable oxidation.

The next most stable fats, monounsaturated fats, are a little bit more flexible and are found in avocados, olive oil, and some nuts (20% of cell membranes). Brain cells hold the most monosaturated fat and maintain a constant level. Fat cells will dump less stable fats in exchange for monounsaturated fat, so eat olive oil.

35% of membranes are made of a combination of polyunsaturated omega-3 and omega-6s. You can get the anti-inflammatory omega-3s from cold-water fish and walnuts and olive oil. Fish is 15% more effective though. Polyunsaturated omega-6s are quite unstable and inflammatory. Eating too much omega-6 fatty acids can contribute to cancer and metabolic problems. Oxidized omega-6s can damage DNA, inflame heart tissue, raise your risk of several types of cancer, and disrupt optimal brain metabolism.

Hydrogenated omega-6 fatty acids (trans fats) are shelf-stable for processed foods. They get used for cell membranes but cannot function properly, resulting in health problems. Frying with omega-6s can form artificial trans fats. If the oil gets used over and over again it becomes oxidized too.

If you are lean, you want to eat the same composition of fats that you want stored in your body (50% saturated, 25% monounsaturated, 15-20% undamaged omega-6 and 5-10% omega-3 (EPA and DHA)). If overweight, eat a higher proportion of saturated and monounsaturated. When testing for heart health it is better to look at CRP and homocysteine than cholesterol and triglyceride levels. The fat levels in the heart, brain, and muscle cells are different to the blood cells.

Pig’s Ears and Energy Fats

Use C8 coconut oil first, then MCT, then maybe coconut oil. Your body doesn’t use MCTs to make membranes and is burned for energy instead. Source from coconut oil, not palm oil.

When exposed to sunlight or mechanical vibration, melanin has the power to break apart water molecules, freeing up oxygen and electrons that mitochondria can use for energy. Our bodies make melanin by linking polyphenols. We stimulate melanin production by eating leafy greens and herbs, tea and coffee, adequate sun exposure, and exercise.

It is possible that the blender breaks apart polyphenols in coffee and yak butter tea into melanin and melanoids, providing free oxygen and electrons.

Coffee + Time = Ketones

Ketones give our brains, muscles, and hearts the energy to hunt. Limiting the eating window to 10 hours reduces triglyceride levels, inflammation, and cancer risk. Sleep improved after a few weeks. Cycle in and out of ketosis every few weeks to maintain metabolic flexibility.

Do these things:

• Avoid conventionally grown grains, produce, and animal products. Or just skip grains altogether and eat more organic vegetables, some organic fruit, and meat from pastured animals
• Don’t eat fried stuff
• Eat enough protein (pastured animals, eggs, wild fish, nonallergenic plants) for tissue repair and 20g+ of grass-fed collagen. Don’t fry, char, or grill meat. 0.5g per pound of bodyweight of protein for lean people. For obese: 0.35g. For athletes: 0.6g
• No matter how much fat you eat, eat the right ratios. Lean people eat 50% saturated, 25% monounsaturated, and 15-20% undamaged omega-6 and omega-3s. If obese: 50-70% saturated, 25-30% monounsaturated, and 10% undamaged omegas
• On some days, limit the eating window to 8-10 hours a day. Have breakfast if you’re tired or stressed. Don’t eat after dark
• Practice a cyclical ketogenic diet by fasting, avoiding carbs for a few days, or adding C8 MCTs or exogenous ketones

4. Sleep Or Die

How Lack of Sleep Will Kill You

One good night of sleep can improve your ability to learn motor skills by 20% and increase your ability to gain new insight into complex problems by 50%. Good quality sleep also promotes skin health and youthful appearance, controls optimal insulin secretion, and encourages healthier cell division. Eating late at night dramatically decreased rat’s sleep quality and lowered the ability to control blood sugar by 50% in one of Satchin Panda’s experiments.

At night, when melatonin is released, insulin producing cells shut down. Meaning blood sugar may spike at night, drop, then adrenaline will be released, waking you up.

Less than 6 hours of sleep leads to increased ghrelin and decreased leptin.

While asleep, the glymphatic system is draining fluids and sending clean cerebral spinal fluid to clear waste and neurotoxins. Without enough sleep, proteins such as amyloid plaques may not get removed, increasing Alzheimer’s risk. Studies in rats have shown that sleeping on one’s side improves glymphatic clearance compared to the back. Humans have lower blood pressure and heart rates when on their sides. The only detriment to lying on the side is vertical wrinkles.

Sleep apnea (increased risk when sleeping on the back) is caused by dysfunctional mitochondria too.

How Much Is Enough?

If you’re constantly stressed, inflamed, and injured you will require a lot more sleep to recover. Eating healthily and managing stress levels may result in slightly less sleep requirements (6-7 hours a night). Best to do a subjective measurement in the morning to gauge potential sickness or recovery needs. Give your body less need to sleep and when you do sleep, do it efficiently.

Sleep Basics

REM/SLOW-WAVE SLEEP:

• Stage 3 is when breathing heart rate drops the lowest and brain waves slow down and get wider (delta waves: 1-4Hz). Helps the brain to recover from learning. Strengthening memory and helps with consolidation, turning short-term memories into long-term. Slow-wave sleep also reduces the level of cortisol and triggers the release of prolactin and growth hormone, which support the immune system.
• For every decade that you live past 30, subtract 12.2 minutes from your total sleep. Your REM sleep will mostly depend on your health status up until 60yo, when you start getting less, unless you do something to stop the decline.
• Teens need 1.7-2 hours of deep sleep, 18yo+ need 1.5-1.8 hours.

HEART RATE VARIABILITY (HRV):

• When the SNS is activated your heart rate becomes very even no matter how fast it beats. The sign of a stressed animal. When the PNS is active, there is greater variability between heartbeats. The same number of heart beats per minute, but less rhythmic when you are relaxed. You are able to recover from stress more easily, reflected by the quick acceleration and deceleration of the heart rate. Low HRV is associated with anxiety disorders and cardiovascular disease, while high HRV is linked to cardiac resilience and overall heart health.
• Without adequate sleep, HRV is reduced from higher stress and SNS activation. Conversely, increasing HRV during the day improves sleep efficiency. Overtraining, chronic stress, obesity, inflammation, and infections all lower HRV. You can increase it by meditating, breathing exercises, a hot bath, sleeping better, eating better, eating fewer toxins, less alcohol, and the right supplements for your biology.

Sleep Better, Not More

Transcranial magnetic stimulation (TMS), triggers the release of slow waves that spread to the rest of the brain. Short auditory tones, 50ms each played at a rate that mimicked the natural changes in the brain neurons during sleep, increased slow waves by nearly 50% during non-REM sleep. Apps like Sonic Sleep Coach can help to detect breathing with your phone’s microphone, and play sounds to encourage deep sleep and REM.

Blue light stimulates intrinsically photosensitive retinal ganglion cells (ipRGCs) in the retina, sending information to the SCN, inhibiting melatonin release. Mitochondria in the eyes have to produce more energy than usual to process blue light. People exposed to high levels of blue light at night have higher risk of developing breast cancer and prostate cancer, obesity, and metabolic disorders. Also, macular degeneration since it is a mitochondrial and potentially a blood coagulation disorder.

Reduce blue-light exposure by:

• Unplugging or covering electrical devices in your bedroom
• Blackout curtains
• Amber or red bulbs at night
• Toss out bright white LED and compact fluorescent lights
• Use glasses to protect your sleep. Blueblockers at night
• Nightshift mode on your phone and computer
• Light filter apps like f.lux or Iris
• Shut down all screens 2 hours before bed
• Carotenoid supplements to protect from oxidative stress caused by blue light. Lutein, zeaxanthin, and astaxanthin
• Increase exposure to high quality light sources before noon

5. Using Light To Gain Super Powers

Step 1: Reduce Junk Light to Live Longer

Blue light suppresses melatonin and low melatonin leads to poor sleep and increased cancer risk. Excess blue light can also cause inflammation and mitochondrial dysfunction, primarily because of its impact on glucose control. In the evening, exposure to blue light causes a peak in glucose levels, leading to higher blood sugar and an increase in insulin resistance. When you are exposed to blue light without the full spectrum of frequencies (e.g. in LED lightbulbs), the free radicals your mitochondria produce fail to send a signal for antioxidants.

We avoid UVB and UVA light, eliminating the response to light that triggers vitamin D production. We need vitamin D for amyloid protein buildup, blood sugar regulation, and setting the circadian rhythm. Red and near infrared (felt as heat) light seems to prepare cells to harness the power of UV rays to produce vitamin D, while protecting themselves from UV light damage, and recovery after the fact.

Using blue light bulbs can actually affect the circadian rhythm of the wildlife around your home too. Not to mention drawing in insects that are attracted to it (which often get killed with pesticides) and removing their part within the ecosystem.

Ways to reduce aging light sources:

• Starting at 8am, dim lights in the house. Switch to red LEDs or candles.
• If you can’t install dimmers, wear glasses that filter blue light.
• Go outside for 10-20 minutes a day to get adequate UV light exposure. Do it before the sun hits its peak and you won’t need sunscreen.

Step 2: Add Beneficial Light Sources to Look Better and Have More Energy

Red/Infrared Light:

• Red/infrared therapy uses these wavelengths to restore, repair, and protect tissue that is injured, degenerating, or at the risk of dying by activating stem cells that normally become latent as we age, while improving mitochondrial function. Increasing the amount of energy mitochondria can produce. It also improves levels of NO, which ensures your cells are nourished by oxygen, blood, and nutrients.
• Infrared light therapy also helps create exclusion zone (EZ) water, the type of water in your cells. Without enough of this water, your cells become dehydrated and mitochondria stop functioning well. Drink raw vegetable juices, fresh spring water, or glacial meltwater. Infrared light causes EZ water to spontaneously form in your cells, boosting mitochondrial function.
• Also effective at treating muscle fatigue and injuries. More stem cells means replacing old cells, more mitochondrial function means less inflammation, and an increase in exercise and circulation means preventing cell loss.
• Wavelengths of 630-670nm (red) and 810-880nm (infrared) are the most effective for healing. Light at these wavelengths penetrate up to 8-10mm into the skin and affect your cells at a biochemical level. Red light can decrease inflammation, improve skin tone, repair sun damage, fade scars and stretch marks, promote hair growth, and stimulate collagen production in the skin. Also, healing wounds and age-related macular degeneration.
• Spending time in a sauna (infrared or not) also leads your body to produce heat shock proteins, which prevent protein degradation caused by oxidative stress. HSPs scavenge free radicals, boost glutathione levels, and make sure proteins retain their proper structure.

Yellow Light:

• Wavelengths of 570-620nm. Increases your mitochondria’s ability to produce ATP, but it doesn’t penetrate as deeply as red or infrared light. Usually used to treat skin conditions and damage from too much sun exposure. Increase collagen, reduce hyperpigmentation, reduce fine lines and wrinkles, speed healing, and smoother skin.

Intravenous Laser Therapy:

• Stresses your cells to produce a hormetic strengthening response. Studies have shown it to reduce inflammation, boost mitochondrial efficiency, and stimulate the production of more ATP. It also produces a huge wave of activated vitamin D3, far more than the sun can achieve.

Do these things:

• 15-20min of natural sun exposure per day.
• Change the bulbs in your home and wear blue light blockers.
• Consider an infrared sauna to aid in detoxification and boost mitochondrial function. For help with wound healing, muscle fatigue, or tissue repair, look into red and infrared light therapy.

Part II: Age Backward

6. Turn Your Brain Back On

Chronic inflammation in the brain from bad food, chronic stress, heavy metal or toxic mold exposure, infections, or circadian rhythm disruption leads to microglial cells creating too much of a protein called progranulin (PGRN). High PGRN is associated with Alzheimer’s, Parkinson’s, ALS, tumors, etc. According to Bredesen, chronic inflammation, insulin resistance, and exposure to toxins are the greatest risk factors for AD.

Vielight for infrared therapy for the brain.

Your body produces insulin degrading enzyme (IDE) to break down excess insulin and also amyloid plaques. However, it cannot do both at the same time. Reduce sugar intake so IDE can be spent clearing amyloid plaques instead. An intervention is 400-1000mcg of chromium picolinate daily with 25-100mg of vanadyl sulfate, ideally at the same time you eat carbohydrates. These minerals lower the blood sugar spike that occurs after meals. Also, eat fiber with carbohydrates to avoid a blood sugar spike.

He follows a high-fat, low-carb meal plan 5-6 days a week and increases the carb intake on the final day to 150g. Focusing on sweet potatoes, squash, and white rice. Cycling in and out of ketosis retrains the mitochondria in your brain to become resilient and metabolically flexible and gives IDE a chance to clear amyloid plaques. Having ketones present in the bloodstream also reduces your levels of progranulin, the damaging protein released by microglia when you are chronically inflamed.

Racetams (piracetam, phenylpiracetam, and aniracetam) raise oxygen in the brain and improve mitochondrial dysfunction after oxidative stress.

• Aniracetam is fat soluble and has shown to increase memory in animals and a mild antidepressant. The only side effects are due to deficiencies of choline. Stack with choline or eat choline rich foods.

Modafinil improves fatigue levels, motivation, reaction time, mood, and vigilance.

Microdosed nicotine decreased memory impairments and mood-related disturbances like anxiety and depression in an AD pilot study. Nicotine can act as an antioxidant in the brain. Nicotine affects peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha), the master regulator of mitochondrial biogenesis. Helping to create more mitochondria in a similar fashion to exercise. Don’t smoke or vape. 1-2mg occasional use.

Microdosed deprenyl (selegiline) stimulates production of dopamine. Which is why it is used for PD patients, to assist tremor and loss of balance caused by dopamine deficiency. MAO-B keeps dopamine levels in check, to prevent things like aggression and paranoia, when there is too much. Selegiline blocks the enzymatic activity of MAO-B. It also increases neurotrophic factors and increases superoxide dismutase.

Coenzyme Q10/Debenone is used by mitochondria to produce energy. When there is too much oxidative stress, coenzyme Q10 gets used up. Statins can reduce levels by up to 40%. 100-200mg per day.

Pyrroloquinoline Quinone (PQQ) is an antioxidant 100 x more powerful than vitamin C at protecting your cells from free radicals. It also stimulates NGF, which helps to grow new neurons and enhance regeneration of peripheral nerves that connect the brain and spinal cord to the rest of the body. Mouse research has shown PQQ to increase mitochondrial density, reduce inflammation, boost metabolism, combat oxidative stress, improve fertility, improve learning and memory ability, and protect the heart. PQQ also activates PCG-1 alpha in the same way that exercise and nicotine do, sparking biogenesis.

• Stabilized disodium salts and active PQQ. Need to be in liposomal form to be absorbed.

L-Theanine is an amino acid in green tea that increases BDNF, promotes relaxation, alertness, and arousal. Shade-grown tea tends to have more L-theanine, chlorophyll, and amino acids.

Lion’s Mane Mushroom (Hericium Erinaceus) supports the brain and nervous system and promotes mental clarity, focus, and memory. They are high in antioxidants and stimulate NGF. 1500mg per serving.

Curcumin 90mg twice per day helps with age-related memory loss, amyloid clearance, and mood. Pair it with bromelain or an oil based capsule to absorb it. Black pepper apparently interferes with cytochrome P450 3A4 liver detox. Preventing you body from clearing toxic compounds.

He Shou Wu (Polygonum Multiflorum) stimulates the body to produce superoxide dismutase. It alos inhibits MAO-B, increasing dopamine levels.

Do these things:

• Keep blood sugar stable. Fiber, low sugar, chromium and vanadium supplements
• Cyclical ketosis
• Low levels of ketones in the system some of the time but not all of the time
• Neurofeedback training if you have trauma, anxiety, or depression
• A cognitive enhancer from the list:
  • Piracetam: Reduces cognitive decline with age
  • Modafinil: Performance enhancing, not anti-aging
  • Nicotine: Low doses can be helpful for aging and cognitive performance
  • Deprenyl: Works on dopamine receptors for cognitive enhancement
  • CoQ10: Helps your mitochondria produce energy
  • PQQ: A powerful antioxidant for anti-aging
  • L-theanine: An amino acid that helps with memory and mental endurance
  • Curcumin: Improves memory and attention while acting as an antioxidant
  • He Shou Wu: Longevity-enhancing antioxidant herb that can also help you regrow and regain color in your hair

7. Metal Bashing

The Poisonous Effects of Metals

Metals have high electrical conductivity and mess with mitochondria, producing oxidative stress. In children under 10, metals can cross the BBB and kill off neurons and reduce IQ.

When lead enters the blood vessels, it damages the cells that line them, hardening arteries and causing plaques to form.

Thallium is used in rat poison, electronics, glass manufacturing, and pharmaceutical industries. It replaces potassium in your cells, making them fail. The oil industry replaced lead with thallium. Kale is excellent at cleaning it out of the soil. Which we then eat.

Mercury causes high blood pressure, cardiovascular disease, and neurotoxicity. Also, impaired cognitive function and motor skills. Found in fish and amalgam fillings. As well as compact fluorescent light bulbs.

Heavy Detox Methods

Glutathione and Other Antioxidants:

• A natural chelating agent, meaning its molecules can form several bonds to a single metal ion. Allowing the body to eliminate them via urine or bile. Glutathione also prevents mercury from entering cells. Other than metal chelation, it also protects fats from oxidation, boosts immunity, recharges other antioxidants, a cofactor for dozens of enzymes that neutralize free radicals, and helps the brain to function. It is produced by the body but can be supplemented. Just be sure to cycle it so your body doesn’t downregulate its own production.
• Alpha-lipoic acid (ALA) can cross the BBB to protect membranes of neurons from heavy metal damage. ALA also regenerates glutathione both inside and outside of cells.
• Low vitamin C levels are associated with low glutathione and excess oxidative stress. It also recycles old glutathione, elevating antioxidant levels in RBCs. Not good to take after workouts since it may blunt the hormetic effect of a workout. Adequate zinc levels will also prevent your body from absorbing lead and cadmium.

Activated charcoal:

• A form of carbon with a massive surface area and strong negative charge. It binds to molecules with a positive charge (adsorption), to be passed. When you eat foods with cadmium, copper, nickel, and lead, activated charcoal can bind up these toxic metals before they can stick to cells.
• Charcoal is made from burning stuff so be careful of the source. He prefers it made from coconut husks washed with acid to remove any heavy metals.

Chlorella:

• In animal studies, chlorella binds well to mercury in the gut. Try consuming it with fish to avoid mercury intake.

Modified Citrus Pectin and Other Fibers:

• Good at removing lead, cadmium, arsenic, and thallium. MCP apparently reduces cancer’s ability to travel through the body. Also at reducing galectin-3, protecting you from harmful bacteria that cause local inflammation and immune activation. However, galectin-3 is essential for young people (under 40) to grow healthy tissues, so avoid unless high levels of heavy metal are present.

EDTA Chelation Therapy:

• EDTA is a synthetic amino acid that binds to metals and diminishes their reactivity and reduces calcification of your arteries. It is also an anticoagulant for the blood. Calcium buildup is usually the result of an imbalance between calcium, vitamin D, and vitamin K2. We need vitamin D to absorb calcium but we need K2 to keep it in place.

Sweat It Out:

• Stack with an infrared sauna. However, it does pull electrolytes from the body so get lots of fluid and salt. HIIT training increases lipolysis, which releases metal stored in fat when it is burned. Working out improves circulation so you can actually clear the metals by providing more oxygen to the liver and kidneys, rather than move them somewhere new. Lipolysis is more effective when adding calcium-D-glucarate, which converts into glucaric acid and supports a crucial detoxification pathway in your liver. It scavenges, binds, and eliminates toxins. Take activated charcoal before a sauna or workout.

Ketosis is another effective way of inducing lipolysis, particularly when fasting.

Do these things:

• Up antioxidant levels. Glutathione, alpha-lipoic acid, zinc orotate, and vitamin C
• Activated charcoal, 500mg to 5g per day and/or modified citrus pectin, 5-15mg per day, away from pharmaceuticals or food. Take chlorella with fish.
• Get metal levels tested if you feel concerned. Consider IV chelation therapy or suppository EDTA chelation therapy under doctor’s supervision.

8. Polluting Your Body With Ozone

Oxygen and Ozone: The Big Os

You can drink ozonated water and administer it intravenously as a form of hormetic stress. Killing off weak and damaged cells, bacteria, viruses, yeast, fungi, and protozoa. Ozone does this by oxidizing lipids in the body, creating lipoperoxides. These peroxide bodies inactivate pathogenic bacteria, viruses, fungi, yeast, and protozoa in different ways. With fungi, it inhibits growth, viruses have their cell-to-virus contact disrupted, bacterial cells have their cell wall destroyed. Ozone therapy is more effective than antibiotics and doesn’t kill off beneficial bacteria and tax the immune system. It actually triggers the production of glutathione and superoxide dismutase and increased interferon (which inhibits virus reproduction), tumor necrosis factor, and interleukin-2.

He used in rectally to recover from his mold toxicity and also used it on his daughter’s infected ear.

Ozone Therapies (don’t do without training)

A 10-pass: Taking out blood, exposing it to oxygen, creating peroxides and WBCs, puts it back in and does it 10 times over. Rejuvenating the body and removing microbial pathogens. Great for mitochondrial health.

You can use it locally either transdermal or via injection on an infected area. Don’t inhale it.

Rectally, the peroxides drain straight to the liver.

Ozonating water and applying to specific areas to treat infection. Swishing the mouth out to avoid gum disease.

Prolozone, injecting into joints to treat chronic pain, help healing, and regeneration.

Ozone, Energy, and NAD

It increases the rate at which RBCs break down glucose to create energy while boosting the amount of oxygen being sent to tissues. It also charges NAD into NAD+. NAD is a coenzyme that your cells need to perform basic functions. Declining by 50% from birth to age 50. The oxidized form, NAD+ grabs an electron from one molecule and while it has a hold of that electron it becomes NADH. NADH then donates an electron and becomes NAD+ again. Ozone therapy adds more electrons to the mix.

Your mitochondria require NAD+ to create energy, your body needs it for maintenance of blood glucose levels at night, for the generation of ketones, proper muscle function, and for nerves to send messages. NAD+ also helps proteins retain their shape so you can avoid amyloid protein buildup. Your cells also use NAD+ to help sirtuin function.

Sirtuins regulate biological pathways and protect cells from oxidative stress. These proteins also play a crucial role in maintaining telomere length.

NAD+ also protects cells from oxidative stress and to repair DNA that has been damaged. It does this by bringing a negative charge to places where DNA is damaged.

The NAD+ to NADH ratio should be 700:1. Raising NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, reduces stem cell senescence, and increases life span in animals. He gets NAD+ IV treatments once a quarter.

Other ways to boost NAD+:

• Tru Niagen supp – nicotinamide riboside, a precursor to NAD+
• Cyclical ketogenic diet, fasting, MCTs, exogenous ketones, etc.
• Intermittent fasting
• Oxaloacetate. Your body converts this organic compound to malate, a salt form of malic acid, which raises your NAD+ to NADH ratio

Do these things:

• Over 50 or health problems in the past? IV ozone treatments with a local doctor
• Arthritis or joint pain? Prolozone injections
• Dental work? Ozone gas to sterilize the teeth before treatments, to avoid chronic inflammation
• Up your NAD+ with supplements or IV treatments to boost mitochondrial function. Or keto, IF, and/or caloric restriction

9. Fertility = Longevity

Sex, Lies, and Hormones

Wiley Protocol of dosing bioidentical hormones for postmenopausal women. As we age we start to produce less DHEA and pregnenolone, pre-hormones to testosterone, estrogen, and progesterone.

DHEA decrease results in skin aging, more body fat, less muscle, lower bone density, crappy sleep, and sexual dysfunction.

Estrogen decline leads to increased cancer, bone loss, and heart disease.

Testosterone decline negatively affects fat burning, muscle building, and sex drive. Even osteoporosis in men, mild cognitive impairment, and Alzheimer’s.

End the Stigma of Hormone Replacement Therapy

In a study, HRT increased breast cancer but reduced other types of cancer. Giving it a bad name. Probably for the best as they were using synthetic hormones. Bioidentical hormones however, cannot be patented, so the funding is lacking. Testosterone therapy got a bad name due to bodybuilder abusing synthetic versions, trashing their livers. There was a myth about it causing prostate cancer too. Whereas low testosterone is associated with prostate cancer.

Before being prescribed, a physician will measure:

• Estradiol – the most potent estrogen
• Estrone or estriol – weaker estrogens (estrone turns into estriol in your body)
• Progesterone – balances estrogen
• Testosterone – necessary for muscles and sexual function
• Prostate-specific antigens (PSA) – for men who are on testosterone, discontinue if it climbs
• Hematocrit – for men who are on test, discontinue if it climbs
• Sex hormone binding globulin (SHBG) – this sticks to hormones to make them unavailable
• DHEA – a pre hormone
• Pregnenolone – a pre hormone

Testosterone:

• Skin cream and a pellet that goes under the skin.

DHEA:

• Recent research suggests it is immune enhancing, anti-diabetic, anti-obesity, anti-cancer, neurotropic, memory enhancing, and anti-aging. Low DHEA is linked to depression and a higher risk of heart attacks and death from all cause mortality. Be careful with injecting as your body will do something different to somebody else. Some people get test improvements whereas as he got man boobs again.

Oxytocin:

• A 2015 study found inhibiting oxytocin reduced muscle repair and stem cell activation, while supplementing improved regeneration and stem cell activation. It also reduces inflammation. A possible reason why having a good social group may extend longevity. He increased social interaction to improve empathy and to better pick up on social cues.

HGH:

• Results are mixed.

What’s Hurting Our Hormones?

A poor diet and exposure to environmental pollutants. Testosterone is down due to low vitamin D, from little sun exposure, and low saturated fat intake. If your testosterone levels are low, take vitamin D3, K2, and vitamin A. Also zinc orotate if you’re low in zinc.

Hormone disrupting chemicals are prevalent. Deodorants, lotions, shampoos, conditioners, shaving creams, and other grooming products. The worst offenders are phthalates, which mimic estrogen and accumulate in your fat cells.

Birth control pills significantly decrease testosterone and contain synthetic estrogen. When the body recognizes the estrogen, your liver responds by sending out SHBG to prevent excess sex hormones from wreaking havoc. It binds to estrogen, testosterone, and DHT. Six months of hormonal contraceptives can keep SHBG levels elevated for as long as six months after stopping.

Hormone Hacks

Exercise:

• A sharp increase in HGH after strength training. HIIT is more effective at increasing testosterone and HGH.
• Endurance exercise and HIIT help to lengthen telomeres.
• Be sure to get adequate sleep so HGH, cortisol, and leptin aren’t negatively affected.

L-tyrosine:

• If your thyroid is sluggish, L-tyrosine can help to upregulate thyroid function to naturally produce more thyroid hormones. L-tyrosine is a precursor to dopamine, epinephrine, and norepinephrine.
• 500-1000mg per day on an empty stomach in the morning.

Do these things:

• Stop eating sugar, soy, excess omega-6, and refined carbs, and replace with healthy saturated fat from grass-fed meat, eggs, and energy fats
• Exercise intensely 1-3 times per week to boost testosterone. Track sleep
• Consider L-tyrosine, vitamin D3, K2, A, and zinc orotate supps. Test first
• Get rid of all phthalates and paraben toiletries
• Explore bioidentical hormone therapy if your levels are deficient
• If over 40 and have clear signs of low sex hormones, try 25-50mg of DHEA

10. You Teeth Are A Window To The Nervous System

The front four teeth emerge from the neural crest when we are embryos and the back molars are directly connected to the brain. Even micro misalignments in the jaw can cause the trigeminal nerve to send a threat message to your ANS.

Excess stress causes the body to store more visceral fat, which is associated with insulin resistance and inhibits adiponectin, a hormone that regulates your levels of body fat. Too little adiponectin causes excess fat and levels decrease with visceral fat. Excess visceral fat leads to stiff arteries and inflammatory cytokines.

Relaxing your jaw can result in decreased musculoskeletal pain. Made possible with a bite guard.

P Is For Pain

The trigeminal nerve is highly sensitive and even the slightest dysfunction that puts pressure on the nerve leads to increased levels of substance P, which sends pain signals to the brain. Substance P is a primordial pain-signaling molecule, and a rise in substance P always causes inflammation. When you bite down and your top teeth on one side touch down first, this stimulates the release of substance P, which tells the brain it is under threat and triggers the release of inflammatory cytokines.

People with asthma, eczema, and psoriasis are often hypersensitive to substance P, meaning their bodies produce excess inflammatory cytokines. Also found in the colons of people with IBD and studies have shown that cancerous tumors overexpress substance P.

Substance P opens up cell membranes, making them less efficient and more vulnerable to toxins that can enter the cell and cause direct damage. Also, substance P plays a role in activating stem cells, so if levels are out of wack, you can’t replace cells that die, and tissues throughout the body will waste away.

Align Your Jaw With Your Life

Along with sleep apnea, the trigeminal nerve is involved with the brain’s reticular activating system, the part of the brain stem that keeps you awake. When you bite down, all your teeth should touch down at once for proper bite alignment.

Dr. Jennings believes that even inner ear infections in children can be explained by orthopedic jaw defects.

When you have an overbite you subconsciously have to slide your lower jaw forward to bite things off, to control your airflow, and to speak. As a result, you create hypermobility in this joint, which impacts the trigeminal system and leads to elevated levels of substance P. TMJ is also correlated with pain in other joints, like knee pain. The trigeminal nerve also plays a role in modulating blood flow to the brain. In particular, how much flows to the PFC. In times of survival, you want to shut down the PFC so you don’t think too much. Meaning, you can’t activate your PFC properly because you’re constantly shifting into fight or flight as a result of poor jaw alignment.

Dental Health Hacks

Cayenne Pepper:

• Capsaicin reduces levels of substance P in the body. The only downside of eating lots of peppers is that a lot of them belong to the nightshade family, which many people (about 20%) are sensitive to. If nightshades cause you inflammation, try pure vanilla bean instead. They both work by interacting with vanilloid receptors.

Oil Pulling:

• An Ayurvedic practice known to detoxify and clean the mouth and gums, reduce inflammation and halitosis, and make teeth whiter. Oil pulling pulls harmful viruses, bacteria, parasites, fungi, and all toxic waste products from the mouth, preventing them from seeping into your bloodstream. Oil binds to biofilm, or plaque on teeth and reduces the number of bacteria in the mouth. MCTs in coconut oil are good at attacking Streptococcus mutans, which cause cavities. Coconut oil is also naturally anti-inflammatory. Adding oregano oil is useful too since it is antifungal and antimicrobial.

Do these things:

• Test jaw alignment by opening your mouth, relaxing your muscles, and slowly biting down. What hit first? You want molars on both sides to hit evenly at the same time and for your front teeth to hit very lightly right after the molars. Buy a bite guard
• Eliminate sugar, try oil pulling, brush occasionally with activated charcoal to sop up toxins
• Find a dentist who will try transcutaneous electrical nerve stimulation or a cold laser if you suffer from TMJ dysfunction or jaw pain for any reason. Reducing substance P levels and taking pressure off the trigeminal nerve

11. Humans Are Walking Petri Dishes

Diversity In The Gut

Some parasites and bacteria may actually improve immune function even though they may be considered “bad” (within reason). There has even been a study suggesting that helminth therapy (parasite supplementation) may help enhance the function of Treg cells and prevent autoimmune disease (MS, IBD, etc.). Rather than using immunosuppressing drugs it is possible to reverse autoimmunity by reducing inflammation and healing the gut instead.

Germs Are Your First Gifts From Mom

Babies born vaginally have a similar microbiome to their mother’s gut biome. Children born via C-section have a similar gut biome to the mother’s skin biome. Breast milk contains up to 600 different species of bacteria that help promote bacterial diversity in a child’s gut.

During the first few years of a baby’s life, their microbiome adjusts from bacteria that can utilize/digest milk to bacteria that can metabolize energy from solid foods. By age 3, their microbiome is similar to an adult’s. The makeup of their microbiome has a huge impact on how their immune system develops. Some gut bacteria species produce short-chain fatty acids which play a role in the proliferation and differentiation of immune cells, including T and B cells, which produce antibodies. A surplus of bad bacteria and/or lack of diversity between birth and age 3 may result in autoimmunity, allergies, and asthma.

Antibiotics wipe out both dangerous and beneficial bacteria, causing a reduction in diversity. Increasing the child’s lifetime risk of developing asthma, eczema, and type 1 diabetes.

• Infants who develop asthma often have low abundance of Bifidobacterium, Akkermansia, and Faecalibacterium and a high relative abundance of fungi like Candida and harmful bacteria that release inflammatory metabolites.

Probiotics Can Make Your Gut Worse

Most probiotics on the market contain histamines. Certain bacteria produce histamine through a fermentation process, e.g. Lactobacillus casei, Lactobacillus reuteri, and Lactobacillus delbrueckii subsp. bulgaricus. We need histamine as a neurotransmitter too, but excess may lead to histamine intolerance (migraines, sinus issues, premature aging, etc.). Too much histamine producing bacteria and not enough diamine oxide (DAO) to break it down. More histamine neutral ones are Streptococcus thermophilus and Lactobacillus rhamnosus.

Avoid the histamine producing bacteria by not eating yogurts and fermented foods like sauerkraut, some kombucha, pickles, fermented soy products, soy sauce, fish sauce, buttermilk, kefir, mature cheese, red wine, breads made with yeast, and processed, smoked, and fermented meat. Eat prebiotic fiber and resistant starch to support healthy bacteria without buying probiotics.

It’s possible to take supplements that contain histamine-degrading bacteria such as Bifidobacterium infantis, Bifidobacterium longum, and Lactobacillus plantarum.

Candida can live on sugar or ketones, so it can’t be starved by going into ketosis. You need an antifungal protocol.

Prebiotic Fiber:

• Vegetables that are rich in soluble fiber like sweet potatoes, Brussels sprouts, and asparagus. Bacteria use the fiber to produce short chain fatty acids like butyrate.
• Grains, legumes, and beans have plenty of fiber but they also contain lectins, which damage your gut lining and cause inflammation, and autoimmune conditions. Agglutinins, or WGA, impair the integrity of your intestinal lining, allowing small molecules to pass through.
• Essentially just eat a lot of green vegetables unless you have SIBO. Go a short period without fiber to kill the bacteria off and then get back to eating the good fiber.
• Shown to: reduce risk of the four killers. 15-30% decreased risk of cardiac-related death and all cause mortality, 16-24% reduction in stroke, and 19% reduction in type 2 diabetes and colorectal and breast cancer. Reduces intestinal and brain inflammation, reducing dementia. Less insulin resistance, waist/hip ratio measurements, LDL cholesterol, and glycated albumin.

Resistant Starch:

• Stays undigested until the colon and acts as a prebiotic there to be used to produce more butyrate.
• RS1 is embedded in the coating of seeds, nuts, grains, and legumes, which means it is packaged with lectins that harm your gut even though bacteria like to eat it.
• RS2 is the resistant granules in green bananas and raw potatoes.
• RS3 is the type of resistant starch formed when certain starchy foods, like white potatoes (nightshade) and white rice are cooked and cooled.
• RS4 is the man-made resistant starch. Polydextrin or modified starch. One study found that it improved insulin resistance and reduced inflammation in women with type 2 diabetes. Just make sure it is a non GMO source, otherwise you’ll also get glyphosate.
• Resistant starch helped to kill precancerous cells in mice prostate cancer studies and reduced inflammation caused by the cancer. Blood sugar and insulin levels don’t rise as it is not digested.
• Obese people tend to have more firmicute bacteria and less bacteroidetes. Eat more spice and vegetables that contain polyphenols, the preferred food source. The more color the more polyphenols typically. Your gut bacteria also affect weight by producing a hormone called fasting-induced adipose factor (FIAF), which tells the body to stop storing fat and to start burning it instead. Starve the bacteria of starch and sugar and they’ll produce FIAF.

Bacterial Fuel and the Gut Lining

The butyric acid that bacteria produces feeds the intestinal wall cells, keeping it strong and healthy, preventing leaky gut syndrome. When you have a “leaky gut”, proteins can get into the bloodstream and trigger allergies or even autoimmune attacks.

Bacterial neurotoxins called lipopolysaccharides (LPS) can get through and impact organs but causing widespread inflammation and disease.

Leaky gut has been linked to autoimmune disease, type 1 diabetes, IBD, celiac disease, MS, and asthma. Also, acne, rosacea, stomachaches, headaches, and fatigue. The prebiotic fiber inulin is useful for repairing the intestinal wall as it feeds the gut bifidobacteria.

Track Your Gut Like You Track Your Sleep

A Viome stool test can analyze the bacteria present and the compounds they are producing. Viome sequences the RNA of the microorganisms. They then send a report of the foods that will feed the bacteria you need.

If Viome is out of your budget, do the following:

• Don’t eat grains, legumes, or nightshades to prevent leaky gut
• Quit eating sugar as bad bacteria love to eat it, potentially causing SIBO and Candida
• Never eat industrially-raised animals because of the antibiotics they receive and the glyphosate in their food, which will harm your gut bacteria
• Eat more prebiotic fiber. Eat a variety of polyphenol rich vegetables, drink coffee and tea, and add 10g of prebiotic fiber like plain acacia fiber
• Add MCT oil. Saturated fatty acids found in coconut oil have antifungal, antibacterial, and antiviral properties
• Grass-fed collagen protein and bone broth. Collagen helps to maintain the gut lining health

Do these things:

• Up the prebiotic fiber, resistant starch, and polyphenol intake and cut back on sugar
• If you have GI issues, cut back on fermented foods, as you may be histamine sensitive
• Get a Viome stool test or other tests like EveryWell

Part III: Heal Like A Deity

12. Virgin Cells And Vampire Blood

Cellular First Responders

Pluripotent stem cells, like embryonic stem cells, have unlimited self-renewal capacity and can differentiate into any type of cell. Stem cell exhaustion causes pain and increased substance P levels, which leads to inflammation.

Stem cells found in marrow aren’t as plentiful as cells found in fat but they have lots of beneficial growth factors. Adipose tissue is rich in stem cells but has less of these growth factors.

Full-Body Makeover With Stem Cells

Exosomes (from umbilical cord stem cells) filled with growth factors made by stem cells, as well as stem cells from bone marrow and adipose tissue. The exosomes are responsible for intracellular communication that trigger the growth of new tissues and blood vessels, controls inflammation, and fights off infection. When stem cells age, they lose the ability to manufacture these exosomes. Stem cells are able to absorb them because they have similar membranes and not genetic material, making the stem cell younger.

Injected Wharton’s jelly, the gelatinous substance that insulates the umbilical cord, into all major joints. Made of bioidentical human-derived hyaluronic acid and chondroitin sulfate, the building blocks of intervertebral discs, joint surfaces, and ligaments.

Deep sleep and REM sleep increased, mental resilience increased, joint recovery, skin rejuvenation, sexual function, etc.

Get More Stem Cells Without Injections

When researchers added boron to frozen stem cells it increased their viability and ability to form bone and cartilage.

• Fast for 24 hours or more to double the regenerative abilities of stem cells
• Short-term calorie restriction also increases stem cell activity
• PPAR agonists increase stem cell performance. Like Actos (pioglitazone). Also, sesamin and fish oil.
• Cut sugar and reverse insulin resistance.
• Lift heavy things.
• Turmeric supplements cause brain stem cells to grow
• Resveratrol supplements have shown to help stem cells stay undifferentiated and to multiply
• Vitamin D3, vitamin C, and green tea extract have a variety of positive effects on stem cell circulation, production, and response.
• Tai chi raised individual stem cell counts in a Chinese study by 3-5 times.
• High quality sleep helps keep them young.

Stay Young Downstairs With Stem Cells and Other Treatments

• Check hormone levels (particularly testosterone and thyroid), blood sugar, blood pressure, and overall cardiovascular health to address sexual function issues.
• GAINSWave treatment uses high-frequency acoustical therapy to break up microplaque in blood vessels and stimulate growth of new blood vessels.
• Practice Kegels to avoid incontinence and to keep these muscles young.

Regenerate With Badass Cancer-Fighting Cells

Induced pluripotent stem cells (iPSCs) are adult stem cells that have been reprogrammed to be “blank slates” with the potential to become any type of cell, like embryonic cells. We also have very small embryonic-like cells (VSELs) that can be activated through culturing and ultrasonic vibration. They contain tissue inhibitors of metalloproteinases (TIMPs), compounds which increase neurogenesis.

NK cells detect and kill tumorous cells before they turn into tumors. You can turn these iPSCs into NK cells.

Instead of growing your NK cells in a lab you can do these instead:

• Spend more time in nature. Evergreen trees give off aromatic compounds called phytocides that increase NK cells.
• Cypress essential oil in a diffuser at night significantly increases NK cell activity and perforin levels.
• Manage stress as chronic stress suppresses NK cell function.

Bathe Your Cells In Virgin Blood

Donating blood extends your life by decreasing ferritin levels. Animal studies showed aged animals that were exposed to young blood reversed brain aging at the molecular, structural, functional, and cognitive levels.

Klotho:

• A protein produced primarily by the kidneys in young people’s blood. Some people have a genetic modification of the Klotho gene (KL-KS variant), which results in higher levels and usually a longer life-span. They also have larger than normal prefrontal cortexes and better cognitive skills. Injecting klotho can reduce kidney and heart damage.
• Alzheimer’s patients have shown decreased klotho levels in their cerebrospinal fluid. Increasing levels in mice improved cognitive function. Mice studies also showed low levels, and improvements after injecting, with type 2 diabetes too.

Do these things to improve Klotho levels:

• Avoid stress
• Exercise
• Supplement with vitamin D3 (K2 and A)
• Control blood pressure. Angiotensin II also suppresses Klotho
• Maintain healthy hormone levels. High test is associated with high Klotho

Copper Peptides (GHK-Cu):

• Your body releases GHK-Cu when you get injured, but it decreases as you age. This peptide attracts immune and skin cells to injury sites for rapid wound healing and increased collagen synthesis. GHK also reduces inflammation and scarring and acts as a powerful antioxidant. It also helps neurons grow faster and strengthens connections.
• Copper deficiency apparently contributes to going gray. GHK may help prevent that, as well as improve skin elasticity and regrow hairs.

Do these things:

• Spend more time in nature to boost NK cells and enhance your immune system
• Consider boron supplements for stem cells. Calcium fructoborate or food grade boron (tetraborate) work well
• Get hormone levels checked. To improve sexual function, do Kegels and GAINSWave treatment
• Try copper peptides topically or injection or IV to enhance wound healing
• Stem cell treatments for major issues

13. Don’t Look Like An Alien: Avoiding Baldness, Grays, And Wrinkles

Build New Skin, Joints, Bones, And Gut Lining With Collagen

80% of collagen is type 1, 2, and 3. Type 1 and 3 provide structure for your skin, muscles, and ligaments, while type 2 is found in cartilage and your eyes. Collagen makes up 80% of your skin and is found in the middle layer called the dermis. It works together with elastin to strengthen the skin and help it snap back when stretched.

At about age 25, you start breaking down more collagen than you build and lose about 1% each year. Excess sun exposure, smoking, too much UV light exposure.

Collagen protein powder is hydrolyzed, meaning it’s been partially broken down into the main amino acids that your body needs to produce more collagen: glycine, proline, and hydroxyproline.

Helping joint health, skin elasticity, intestinal lining, glycine helps produce stomach acid, therefore digestion.

Heart burn is caused by not enough stomach acid. It causes the esophageal sphincter to open until there is enough stomach acid to break down and sterilize food.

Glycine is also an inhibitory neurotransmitter, which calms the nervous system and can improve sleep.

The body also needs vitamin C to produce collagen. It is a powerful antioxidant, so it protects your skin cells from free radicals that break collagen down and it helps to assemble amino acids into collagen.

Cryotherapy:

• Increases collagen production and blocks inflammatory enzymes and hormones that destroy collagen. Temperature drops can also increase glutathione and superoxide dismutase production.
• Cold exposure helps mitochondria and stimulates capillary beds to increase circulation in your skin. Mitochondria change cardiolipin levels, which are a component of the inner mitochondrial membrane, so they can produce heat more quickly.

Microneedling:

• Disrupts collagen and stimulates the body to form new, youthful collagen fibers. You can also combine this with platelet-rich plasma (PRP) in a treatment called vampire facials. Your blood is separated from plasma, which contains growth factors, then it is applied to the face before and after microneedling to further stimulate the growth factors. Good for healing acne scarring.

Retinol:

• Pure vitamin A. Retinoic acid purges old skin cells and causes new, healthy cells to form quickly, increasing collagen production. It makes your skin more sensitive to UV light and may burn if you already have sensitive skin though. Bakuchiol can mimic the activity without negative effects.

Methylene Blue:

• A powerful cognitive enhancer and acts as a mitochondrial antioxidant. It can also delay connective tissue aging.

Laser Facials:

• Remove surface layers of skin.

Melanin:

• Alpha-melanocyte stimulating hormone stimulates melanin production and is also an anti-inflammatory hormone, which people with autoimmune conditions and toxic mold exposure have low levels of. Consume extra polyphenols.

The Longevity Of Your Hair

As we grow older, catalase production decreases and we don’t have enough to break down hydrogen peroxide that our hair follicles produce, damaging melanocytes. Glutathione can also help break hydrogen peroxide down. Ashwagandha, curcumin, saw palmetto, and vitamin E can ramp up catalase production.

A shortage of MITF (a gene which is attacked during stressful infections) triggered the immune system to further attack melanocytes, leading to gray hair.

Too much DHT causes hair follicles to shrink, leading to baldness. Mitochondrial dysfunction may cause baldness too.

Stress, toxins accumulating in the liver, hormonal imbalances, inflammation, and free radicals affect T3 and progesterone, which modulate mitochondrial activity. Cortisol inhibits TSH, which inhibits the production of T4, which must be converted into T3 to be used. Without enough T4 or the energy to convert it, it gets converted into the inactive reverse T3 instead. Symptoms of low thyroid function include hair loss and may be found with a T3/RT3 test. Stress causes your body to make more RT3, less T3, and mitochondria can’t produce enough energy.

Thyroid hormone disruption can also cause the stem cells in the hair follicle to bulge since they can’t be activated by T3.

Danshen upregulates Wnt, which allows the signal from thyroid hormones to stimulate the production of new hair follicles.

High levels of RT3 and not enough T3 leads to downregulation of progesterone, which causes estrogen dominance. With disrupted estrogen levels, you don’t make collagen efficiently.

Do these things for skin:

• Grass-fed or pastured collagen protein (10g per day)
• Eat more foods containing polyphenols and antioxidants: vegetables, coffee, tea, and chocolate. Vitamin C too
• Cryotherapy, microneedling, and retinol, copper peptides, and methylene blue
• Yellow light therapy

Do these things for hair:

• Avoid phthalates, parabens, and benzophenones. Consider avoiding birth control pills
• To avoid grays, ramp up catalase production by taking antioxidants like ashwagandha, curcumin, saw palmetto, and vitamin E
• Try a DHT blocking shampoo for baldness
• Deal with stress
• If you are balding prematurely, get thyroid levels checked by getting a RT3/T3 levels test
• To stimulate blood flow to the scalp, get a head massage

14. Hack Your Longevity Like A Russian

Peptides

Bioregulator Peptides:

• Synthesized bioregulators are called cytogens. Crystagen is designed to restore immune function, vesugen is meant to improve blood vessel protein synthesis, pinealon is for better protein synthesis in the brain.

Healing Peptides:

• TB500: Made by the thymus gland and produces T cells. Research shows it promotes wound healing and decreases inflammation, helps regenerate blood vessels, and increases stamina. These peptides can be used to treat diabetes gastritis, gastric ulcers, prevent cancer, treat infertility, and normalize immune function.
• BPC157: Reduces inflammation and promotes rapid wound healing. Promotes tendon and ligament healing, heals the gut lining, and repairs damage stemming form IBD.

SARMS

Build muscle and burn fat without the negative effects of steroids.

• MK-2866 (Ostarine): Weaker but still effective at building muscle. A risk of testosterone suppression. 15-20mg daily for four weeks. Do a post-cycle therapy with ashwagandha.
• LGD-4033 (Ligandrol or Anabolicum): Better studied SARM that provides muscle mass increase with a slight testosterone suppression. 2-5mg daily for four weeks. The more you use the greater the effect and the greater the test drop. Wait a month before using again.
• GW501516 (Cardarine): Not technically a SARM because it doesn’t affect hormone receptors. Increases muscular endurance and mitochondrial growth (mice). 5mg in the morning and 5mg in the afternoon. A study found cancer in high amounts.
• SR9009 (Stenabolic): Increased endurance and fat burning, decreased inflammation, and stimulate new mitochondrial growth in muscle cells with mice studies. Needed to be injected and not sure about human usage.

Additional Super Human Compounds

Low-Dose Naltrexone:

• Opioid receptor antagonist, blocking the effects of opioids. Used to treat alcohol and drug addiction. Reduced Crohn’s symptoms and an anti-inflammatory agent in the CNS. Used for fibromyalgia pain, tumor suppression in patients with ovarian cancer, and B-cell lymphoma, pancreatic cancer, squamous cell carcinoma of the head and neck, and colon cancer.
• At a low dose, heroin raises HGH. Abuse shortens telomeres, especially in the brain, and are addictive.

Carbon 60 for a 90% Longer Life:

• 60 carbon structure atom. Buckminsterfullerene. Carbon 60 is a superconductor, which may be why studies have shown it to help mitochondria efficiently complete the chemical process to produce energy. Researchers concluded the dramatic life extension in mice was due to attenuation of age-associated increases in oxidative stress. 2tsp of Carbon60 Plus.

Do these things:

• Try a bioregulator peptide that will help you reduce your risk of one of the four killers
• If suffering from an autoimmune disease or cancer, talk to your doctor about low-dose Naltrexone.
• Try Carbon60 Plus