Author: Steven R. Gundry, MD
Topics: Nutrition
All information is attributed to the author. Except in the case where we may have misunderstood a concept and summarized incorrectly. These notes are only for reference and we always suggest reading from the original source. This summary in particular is derived from older notes that are less comprehensive.
Plants release toxic chemicals to prevent themselves from being eaten. Certain fruits and vegetables have skins, shells or seeds that contain lectins, which cause digestive issues. Gluten is an example of a lectin. Plants appeared on land 450mya and insects 90mya later.
Some seeds have a protective hull that allows them to pass through the digestive system of birds, to be excreted further away, with faeces as fertilizer. The plant will generally be an appealing color to tell a bird when it is ripe. If not, it will be a less bright color, like a green apple. Red and yellow indicate sweetness. If the animal can’t interpret this, the plant will release toxins that encourage them to avoid it. When ripe, the seed hull hardens. Sugar content is at its height. The plant produces fructose, not glucose, which doesn’t release insulin or cause leptin to tell the host it is full. This leads to the human or primate eating excessive amounts of fruit, and spreading the seeds further.
When fruit is being sent to the other side of the world unripe, it is blasted with ethylene oxide to give it the appearance of ripeness. Lectin content remains high.
Naked seeds do not require transport within the body of an animal, as they are usually living in an area of dense nutrition and high fertility. Once the parent plant dies in winter, the offspring replace them. The naked seeds contain chemicals that weaken predators, paralyze them or make them ill. These substances contain phytates (antinutrients) which prevent absorption of minerals in the diet; trypsin inhibitors, which stop digestive enzymes doing their job; and lectins, which are designed to disrupt cellular communication by causing gaps in the intestinal wall. Whole grains contain all three in fibrous hull, husk and bran. Tomatoes, eggplants, peppers, goji berries, beans and legumes are highly inflammatory. Tannins and alkaloids cause the bitter taste. As a bug starts eating the leaves of a plant the lectin doubles on the other side in an attempt to dissuade them from eating.
Lectins bind to carbohydrates, and particularly polysaccharides, in the predator’s body after it consumes the plant. They also bind to sialic acid, a sugar molecule found in the gut, in the brain, between nerve endings, joints, bodily fluids and blood vessel linings. They are sticky proteins that interrupt messaging between cells or otherwise cause toxic or inflammatory reactions. They also facilitate binding of bacteria and viruses. Wheat germ agglutination also encourages weight gain, which was good for our ancestors. Cows get fed up on corn and soy (which are full of lectins) to fatten them up. They get heartburn and pain swallowing, so they are given Ca++ carbonate to stop it.
Our Defense:
Lectin Attack Strategy:
Cooking partially breaks it down. Plus it can break down the cell wall of a plant. This meant we could eat tubers by breaking down the indigestible plant compounds.
Changes in the human diet:
Chronic sinus issues are caused by lectin binding to mucus as it is the first line of defense.
In those sensitive to gluten, they get Celiac’s, and the less sensitive may get brain fog, joint pain and inflammation.
Wheat Germ Agglutinin (WGA):
The WGA has an affinity to bind to joint cartilage and stimulate the immune system to attack the joints. Drugs such as NSAIDs can temporarily alleviate the inflammation and pain, but they have deleterious effects on the gut. Glucosamine occurs naturally and is found in the fluid that surrounds the joints, where its serves its role as a building block of cartilage. Glucosamine binds to WGA, relieving the inflammation and therefore the pain.
Yeast digests the gluten in European breads. USA made breads have trans-glutaminase instead of yeast for rising and is also a binding agent. European white breads contain gluten but not WGA. In sourdough, bacteria and yeast eat the lectins and a lot of the sugars leaving it as the safest for blood sugar spikes. Most gluten free products have trans-glutaminase to make them fluffier and more appealing and in meat and seafood to bind it together. It passes the BBB and acts as a neurotransmitter disruptor, which can cause gluten ataxia (similar to Parkinson’s). It sensitizes us to gluten even if we aren’t gluten-sensitive. Also, dangerous preservatives such as butyl hydroxytoluene, are used to block the oxidation of polyunsaturated oils in the whole grains. This is a major endocrine disruptor, acting like estrogen, prompting fat storage, early puberty in girls and man-boobs on seven year old boys.
A lot of ‘slim’ women suffer from hypothyroidism, arthritis, acid reflux, osteoporosis, bowel issues and depression + the drugs to suppress them all (NSAIDS for pain; Prilosec, Prevacid, or Nexium for reflux). From eating ‘healthy’ foods such as whole wheat pasta, bagels, low fat cream cheese, egg white omelets and salads with dressing on the side. They avoid fats but need statin drugs to reduce cholesterol. The larger women had undergone diets and been told depression, hormone problems, or anxiety was their problem by doctors.
The Anti-inflammatory diet includes:
Avoiding them may resolve:
You inherit your initial holobiome from your mother when you pass through the birth canal. Lactobacilli migrate to the vagina in the last 3 months of pregnancy, as they thrive on lactose. The infant requires these to break down oligosaccharides in the mother’s milk. Without a normal set of microbes, your immune system can’t develop properly. If born via cesarean section it may take 6 months.
Consuming over the counter painkillers, particularly non-steroidal anti-inflammatory drugs (NSAIDs) – lectins and LPS can breach the intestinal border. With the exception of WGA, lectins are big proteins. They are adept at prying apart tight junctions between the cells. When lectins and LPS get in, the immune system perceives them as a threat, tells the body to store fat, and attacks. The binding also prevents vitamins and nutrients from getting across. Intestinal webs (blockages caused by webs of tissue) may occur after use of regular NSAIDs. due to damage they cause to the lining.
Friendly bacteria in the gut (the mucous layers), thrive on complex resistant starches called fructo-oligosaccharides. They also stimulate mucosal cells to produce more. Mucus then acts as a trap for lectins, so the more mucus you have, the more resistant you are, unless you take NSAIDs. NSAIDs blow gaping holes in the mucus-lined intestinal barrier resulting in LPS, lectins and other bacteria invading. The immune system responds with inflammation and pain.
Drugs change the gut flora and mucus lining. Just as smoking can change the oxygen absorptive capacity of the lungs, lectins can savage the absorption of the intestine. Lectins can reach the brain by the blood and the vagus nerve.
To resolve Crohn’s, you remove the lectins and rebuild the gut wall with vitamin D3, prebiotics, and probiotics.
As a previous summary – Whole grains introduce lectins, particularly WGA into the gut. Both whole grains and transglutaminase initiate the intestinal leakage of LPSs into the bloodstream and incite hormone mimicry, and transglutaminase sensitizes you to glutens, even if you aren’t sensitive.
Disruptor 1: Broad spectrum antibiotics
When using broad spectrum antibiotics, you kill all microbiota in the gut and it may take up to 2 years for them to return. The likelihood of a child developing Crohn’s, asthma, diabetes and obesity increases. A single dose of broad spectrum antibiotics to a pregnant woman can make her kid fat and the same effect can occur when given to a child. By altering your intestinal flora, which communicates with the immune system, antibiotics cause your body to go into a war state, increasing fat storage so your immune cells have the fuel to fight infection. Antibiotics from the flesh and milk of animals also magnify the effect.
Disruptor 2: NSAIDs
Summary – NSAIDs damage mucosal lining and intestinal wall causing LPSs to escape, causing more inflammation and pain.
Disruptor 3: Stomach Acid Blockers
Probiotics must be in spore form or enteric coated. Stomach acid blockers are usually proton pump inhibitors (PPI) and without stomach acid to kill bacteria, the bacteria can overgrow and alter gut flora. Also, bacteria can crawl up into the small intestine where it doesn’t belong. The stomach acid blockers can kill off the mitochondria’s ability to produce energy via their own proton pumps. One study showed a 44% increase in dementia risk among 74000 people aged 75+ who had used these drugs. PPIs have been linked to kidney disease for the same reason. People who use them are 3x more likely to get pneumonia and foster incomplete protein digestion. Since lectins are proteins, this allows more lectins into the gut. Finally, because stomach acid is required to break down amino acids to be absorbed, we have protein malnourishment. This leads to sarcopenia.
Disruptor 4: Artificial sweeteners
A single packet of Splenda kills 50% of normal intestinal flora, then you gain weight as a defense mechanism. The taste of sweetness is the sign winter is approaching and to eat fruit to store fat. When you taste artificial sweeteners, but no glucose goes to the bloodstream, the brain tells you to eat more, leading to weight gain.
Healthier alternative – Stevia. Still stimulates an insulin response making you want more.
Disruptor 5: Endocrine disruptors
May cause problems such as:
Many compounds are used as preservatives or stabilizers; an example is butyl hydroxytoluene (BHT), which is used to preserve whole-grain products. Discarded omega 6 oxidizes, so BHT prevents spoilage. Bisphenol (BPA) is used in bottles and other plastic to keep it heat resistant and tough in the plastic lining of cans. Parabens in cosmetics and sunscreen have the same purpose. Methylparaben is a major allergen used to preserve drug solutions. Tert-butylhydroquinonet (tBHQ), a synthetic food preservative, is in bread, waffles, crackers, and other baked goods, as well as cooking oil and nuts (although it doesn’t need to be on the label). Consuming tBHQ stimulates T cells, to release proteins that can stimulate an allergic reaction to fish, wheat, nuts, shellfish, etc. Antibacterial chemicals destroy microbes and also act like estrogen.
The good bugs in your mouth are responsible for taking compounds your exhale and converting them into a potent chemical that dilates your blood vessels and promotes normal blood pressure. Mouthwash kills bacteria and leads to increased blood pressure.
Sunscreen prevents the absorption of vitamin D and also lowers the liver’s ability to convert it to its active form. This prevents regeneration of new cells in your protective intestinal wall barrier, allowing more lectins and LPSs through, along with foreign bodies. Men with prostate cancer have low vitamin D.
Most hormone disruptors mimic estrogen, which tells cells to store fat in the approach to pregnancy. Estrogen-like compounds bind to receptors and remain permanently switched on.
The more chicken a pregnant woman eats, the smaller her baby boy’s penis, and the shorter his attention span. Arsenic and phthalates in the chicken cause estrogen mimicking, which impact sexual imprinting and gender identity too.
Azodicarbonamide is used to bleach flour, condition dough and is found in yoga mats, carpet underlay, etc. as a foaming agent. It provokes asthma, allergies and suppresses immune function. It also breaks gluten into gliadin and glutenin making them more available and irritating.
Disruptor 6: GMO food and the herbicide roundup
The GMO plant produces novel proteins and/or lectins that our TLRs recognize as foreign, causing inflammation when we eat them. Glyphosate from roundup remains on beans and grains to be fed to livestock and it gets in their meat, milk and fat.
The husk, which is covered in the pesticide, gets left on for its “whole grain goodness” which we eat. It blocks the shikimate pathway and bacteria can’t produce tryptophan, tyrosine and phenylalanine (Tryptophan and Phenylalanine produce serotonin and tyrosine and phenyl are essential for thyroid hormone). Roundup also paralyzes key liver enzymes (cytochrome P450 enzymes) that convert vitamin D to a form your body can use to recycle cholesterol – meaning it raises cholesterol. Plus you need the vitamin D to foster repair of the now-damaged wall.
True meanings
Disruptor 7: Constant exposure to blue light
The seasonal cycle where we switch from glucose to ketones as a fuel source is called metabolic flexibility. Instructions for this cycling are mediated by blue light. Blue light stimulates ghrelin and cortisol and suppresses the production of melatonin.
When LPS and lectins breach the intestine’s walls, your body goes on the defensive. In order to have sufficient calories to fuel the WBC your muscles become insulin and leptin resistant (metabolic syndrome), not because we are fat, we’re fat because we’re saving calories for the war effort.
Based on skeletal remains we know 12,000 years ago our ancestors were about 6ft tall. Once the agricultural revolution occurred the average shrunk to 4ft10inches. Arthritis appeared and brains shrunk by 15%.
If the lectin, WGA, fits into an insulin receptor docking port:
So in summary, less muscle mass, starved brain and nerve cells, and plenty of fat. Recently it has been found that lectins climb the vagus nerve to the substantia nigra, contributing to damage causing Parkinson’s. More prevalent in vegetarians and reduced in Chinese experiments where the vagus nerve was cut to stop ulcers.
As the “war” is being fought in the intestine, there is fat being stored around the belly and in the arteries. Fat in the pericardial arteries and the brain is a sign you are losing the “war”.
The problem with low carb diets…
Our forefathers most likely subsisted on tubers, berries, nuts, and animal protein sources such as fish, lizards, snails, insects and small rodents. Most success gained from paleo and other low carb diets is from restricting the lectin foods. Tomatoes, zucchini “noodles”, bell peppers, goji berries, peanuts, cashews, sunflower seeds, and chia or pumpkin seeds are not ancestral foods – and are loaded with lectins.
Reasons for low-fat diet loss…
Rice has no WGA, nor does taro root, millet, sorghum, and yams. Humans, elephants, shellfish, mollusks, and chickens have lectin-binding sugar Neu5Ac, but grain-eating chimps have Neu5Gc. This is why chimps don’t get atherosclerosis or autoimmune disease from eating lectins but humans and elephants do.
Neu5Gc looks a lot like Neu5Ac, so when you eat cattle, pigs and sheep you develop an antibody to your own lining of blood vessels which results in friendly fire. This is why shellfish and fish eaters fare better. Cancer cells also use Neu5Gc to attract blood vessel growth toward them via vascular endothelial growth factor (VEGF). VEGF is promoted by immune attack on Neu5Gc. Tumors have lots of them, which can only be from animal meat. In summary, the reason to avoid red meat is to prevent autoimmune attacks that promote heart disease and cancer, all because of a genetic mutation of a lectin binding sugar molecule.
The leaves gorillas digest get broken down by gut bacteria, which turns them into fat to be used as a fuel source.
Revamp your habits:
Rule 1: What you stop eating has far more impact on your health than what you start eating.
A water fast can do wonders. All disease begins in the gut. Your gut holobiome makes up 90% of the cells that make up “you”.
Rule 2: Pay attention to the care and feeding of your gut bugs, and they will handle the care and feeding of you. After all, you are their home.
Give the bugs what they want, avoid NSAIDs, antacids, antibiotics and the Western high-fat, high-sugar diet. Stop feeding the gang members and they’ll leave town.
Rule 3: Fruit may as well be candy
If it has seeds, it is fruit (zucchini, tomato, bell pepper, eggplant and pickle). Eating the fructose in fruit causes the kidneys to swell and suffer injury. You can eat bananas, mangoes, and green papayas as long as they are unripe (they haven’t increased fructose content yet). Instead it is made up of resistant starches. Green banana flour can be useful. Avocado has good fat and soluble fiber, which will help you lose weight and absorb fat soluble vitamins and antioxidants.
Rule 4: You are what the things you are eating ate.
Corn has been genetically modified in the US to have a potent lectin that improves insect resistance. Once that is fed to cows, chickens and pigs and you eat the meat and drink the milk, it makes its way into you. This is a lectin to which everybody reacts, and is even found in the breast milk of American mothers. It causes osteopenia and osteoporosis in chickens. Chickens, pork, beef, and cow’s milk is also full of aflatoxins, toxic by-products of molds and fungi that grow on corn, wheat, and soybeans. This has been linked to genetic changes and cancer.
Phase 1: This 3 day cleanse begins the process of repairing your gut, fortifying the good microbes, and banishing most of the bad microbes. At the end of the 3 days, your gut organisms will have changed, and therefore, your gut has changed. But you must move directly on to Phase 2 to prevent the almost immediate return of the bad microbes.
Phase 2: After 2 weeks, you will feel and see the change. After 6 weeks you’ll have engrained these new eating habits.
Instead, you’ll consume the following:
Phase 3 (optional):
Pressure cookers will destroy the lectins in beans and other legumes, as well as nightshade and squash families. Pressure cooked beans serve as a smorgasbord for your gut microbiome, and can improve longevity and enhance memory. Most whole foods stores stock brands not lined with BPA. Unfortunately, the lectins in wheat, rye, barley, and oats cannot be destroyed. Using them in other grains and pseudograins can destroy the lectins. Do not introduce those foods until phase 3.
Overconsuming and metabolizing large amounts of protein into sugar is associated with high blood sugar levels, obesity, and a shorter life span. Certain amino acids in animal protein – methionine, leucine, and isoleucine – seem to be the real culprits for promoting rapid aging and cancer growth.0.37g of protein per kg of bodyweight is a good gauge. Our protein requirements are actually quite small because we recycle most of the cells that die and break down.
Common excuses:
Excuse #1: You are already slim, fit, and active
Your LDL:HDL ratio may be out still or you could carry the APOe4 gene.
Excuse #2: You are worried that the program requires a deep understanding of human metabolism and nutritional concepts
Excuse #3: You’re too old to make significant changes in your eating and other habits (or think your loved ones are)
You replace 90% of your cells every three months, regardless of your age. So, giving those new cells high-quality building materials to work with via the foods you eat and what you feed your bugs will make a new you.
Component 1: On and Off the menu
Protein:
Fats and oils:
Snacks:
Beverages:
Don’t forget:
Do the best you can. Obviously there will be times where it isn’t possible to stick to the schedule, but the better you do the better the results of the cleanse.
Component 2: Prepare the soil and remove the weeds
Swiss Kriss herbal laxative will clean the system out to start fresh. The active ingredient is the laxative herb senna, or sennosides – each tablet containing 8.5mg. Other bad bacteria destroying things include anise seed, calendula flower, caraway seed, hibiscus, peach leaves, peppermint oil, and strawberry leaves. Optional, but take the night before the cleanse with water. No need to repeat afterwards.
Component 3: Supplemental assistance
If you suffer from IBS, leaky gut, etc. try these supplements:
After 3 days you will:
*Tips for success **
You will get to eat great food, but you will likely miss all the addictive (and inflammatory) foods to which it is accustomed. You may experience hunger and energy depletion. If you find you are still hungry have more of the approved vegetables but don’t exceed two servings of guacamole or avocado or any additional servings of fish or chicken. Try drinking more water first. By day four, your energy will return in spades, jeans will be looser and you can move on to phase 2.
The definition of an addict is someone who uses or eats something that they know are killing them, but does so nonetheless. Just spend two weeks doing this to see changes, and 6 weeks to instill habits.
The “No” section is called this because no human ate these 10,000 years ago. Grains, pseudograins, and beans were not part of our diet. Evolution does not work that fast. Not all lectins are problematic, but it takes a lot of time to handle them. You are not eliminating ALL lectins. You can control which ones you consume. 5 raw black beans or kidney beans will clot your bloodstream within 5min. Ricin, the lectin found in the castor bean, a plant native to Africa but now thriving in Southern California, is the most potent lectin known. A couple of molecules will kill you within minutes. You may get omega-3 from chia seeds but the inflammation from lectin outweighs the benefits. The Incas had 3 detoxification processes to make it edible: they soaked it, fermented it, and cooked it.
LPSs require long chain fatty acids to transport into cells. MCTs can’t be used and omega-3s block entry. The saturated fats can’t be transported through the gut without chylomicrons. The LPS stow away on chylomicrons, which are forced to carry the long chain saturated fats. Olive oil can also act as transport so must be limited for the first few weeks.
A recent study showed saturated fats, such as lard, increase hunger and appetite by delivering LPSs to the brain’s hunger center. Fish oil does the opposite.
Plugging the holes:
Feeding the gut microbiome:
Additional important supplements:
This is considered the lifestyle part.
Amino acids, particularly methionine, leucine, and isoleucine, which are far more prevalent in animal protein than plant, activates the cellular sensor of energy availability, mTOR, or just TOR, for target of rapamycin. TOR senses energy availability and stimulates it is time to grow and stimulates cellular growth by activating IGF-1. Low IGF-1 = longevity. The risk of Alzheimer’s is directly correlated with meat consumed.
Fasting
Humans once fasted regularly, not because it was trendy or they wanted to cleanse their gut, but rather for the fact that food wasn’t always available. 23 obese people were put on a 60 day fast and were injected with insulin to remove glucose from the blood. They got severe hypoglycemia, sweats, low BP, and fainting. At the end of the 60 days they were injected again and they were completely awake and alert. They no longer required glucose and used ketones instead.
Mitochondria:
Hundreds of millions of years ago small bacteria (ancestors of mitochondria) built a symbiotic relationship with host cells and stayed on to produce ATP. They have their own DNA, which divides at the same time as the host cells. Mitochondria shoulder the workload of handling the calories you consume, using sugars and fats to produce ATP in the Krebs cycle. They used to use the circadian rhythm to rest a little at night. They have a slow burn in the absence of sugar and protein intake, relying on ketones. During the summer they work overtime and occasionally refuse entry to the sugar and protein and store fat in your belly. It only takes half the effort to turn ketones into ATP than glucose. When you overwork them there is an energy deficit to the brain and body. Immune system gets low as too much energy cost. Cancer cells start using the free sugar lying around.
Insulin instructs an enzyme called lipoprotein lipase to make fat cells turn sugar into more fat to store. If you continue eating sugar, protein and lectins, your pancreas keeps pumping out insulin, which leads to resistance.
Mitochondria cannot process fat directly from fat cells. Instead, an enzyme called hormone-sensitive lipase has to turn on stored fat into a usable form of fat called a ketone. Insulin stops it from working. In winter the lipase is unblocked and it makes ketones to send to mitochondria. Eating fat is the key to unlock the fat storage in those with high insulin levels. It also stops keto flu. Butyrate (ketone in butter), the short chain fatty acid in butter, goat butter, and ghee is a small source of ketones. Eating high protein turns into sugar so you can’t eat heavy meat products when trying to get into ketosis.
Cancer cell mitochondria use the inefficient system of sugar fermentation also used by yeast and bacteria. The average cancer cell needs 18 x more sugar to grow and divide than normal cells. Cancer cells also prefer fructose than glucose.
Fructose is one of the leading causes of kidney failure. Fructose is a toxin that 60% of is shunted towards the liver, where it is converted to the form of fat called triglycerides (which cause heart disease) and to uric acid, which raises blood pressure, causes gout, and directly damages your kidney’s filtration system.
Boost Fat Burning:
IF takes the load off of mitochondria, but if you don’t have the metabolic flexibility you should supplement with a tablespoon of MCT or coconut oil every few hours.
Fruits, vegetables, and grains no longer contain enough of certain needed nutrients. The soil has been depleted of the nutrients after mass farming and unsustainable farming practices.
Vitamin D3:
5000-10000IUs. All autoimmune people were deficient. No sign of toxicity.
B vitamins, especially Methylfolate and Methylcobalamin:
Many B vitamins are produced by gut bacteria, so if your microbiome has been destroyed you are most likely deficient in methylfolate (folic acid) and methylcobalamin (active b12). More than half of the world’s population has one or more mutations of the methylenetetrahydrofolate reductase (MTHFR) genes, which limits the ability to make active forms of both vitamins. You can take 1000-5000mcg nethyl b12 to bypass the mutation. You may have excitability or depression. The b vitamins contribute a methyl group to an amino acid called homocysteine in your bloodstream and convert it to a harmless substance. Elevated levels of homocysteine are correlated with damage to the inner lining of your blood vessels like high cholesterol.
Polyphenols:
Plants design these compounds to resist insects and protect against sunburn, so they provide you with a host of beneficial effects when metabolized by your gut bacteria. These include blocking the formation of artherosclerosis – causing trimethylamine N-oxide (TMAO) from the animal proteins carnitine and choline and actively dilating your blood vessels. Grape seed extract, pine tree bark extract, and resveratrol, green tea extract, berberine, cocoa powder, cinnamon, mulberry, and pomegranate.
Green Plant Phytochemicals:
Suppress your appetite for the bad stuff. Spinach reduces hunger for simple sugars and fats. Modified citrus pectin and FOS also helps with suppression and gut buddy stimulators.
Prebiotics:
They are the compounds the probiotics eat to grow. Psyllium husk acts as food for your gut. Inulin, an FOS is one of the best. Mother’s milk has galactooligosaccharides (GOS), which are designed to feed the gut of the newborn.
Lectin blockers:
Glucosamine and MSM can help. Also consider D-mannose – the active ingredient in cranberries.
Sugar Defense:
Chromium, zinc, selenium, cinnamon bark extract, berberine, turmeric extract, and black pepper extract. Very little turmeric reaches your bloodstream even with black pepper. Curcumin is one of the few antioxidants that crosses the BBB.
Long-chain Omega-3s:
Half the fat in your brain is DHA, and the other half is arachidonic acid (AA) – a great source of which is egg yolk. Higher omega-3 correlates with a better memory and a bigger brain. Fish oil helps repair the gut wall and keeps LPSs from crossing the gut lining.