In Progress
Keep in mind that everybody has a greater genetic disposition to being naturally better at specific physical activities. Diverging from these preferred variations of movement often results in slow technical and physical development, where it would be more efficient to train in an activity that your body “craves”.
Measuring Exercise and Physical Performance
Methods to Improve Physical Performance
What Kind of Weight Training Is Best?
Exercise and Immunity
Muscle Mass and Immuno-senescence
Overtraining
Fasting and Intermittent Fasting While Training
The main areas of exercise performance:
Aerobic Fitness: The ability to utilize oxygen for low-intensity, higher-endurance activity. Cardiovascular and respiratory fitness are related to aerobic fitness and the ability of the body to use inhaled oxygen for fuel.
UKK walk test for VO2 max/oxygen uptake:
Walk 2km, on a flat surface, as fast as possible. Adequate accuracy is achieved when the heart rate is at least 80% of maximum. Not recommended for people with very high fitness.
Clinical exercise stress test (exercise ECG):
Usually done on a bicycle to detect cardiovascular disease potential. Good for measuring aerobic fitness and anaerobic force generation, as it is performed to exhaustion. Arterial blood oxygen and lung function may also be measured. Athletes usually undergo more comprehensive testing, i.e. running spiroergometry. This tests for oxygen consumption and CO2 production and therefore anaerobic threshold. The more comprehensive version can measure lactic acid level in arterial blood.
Cooper test:
Involves running as far as possible in 12 minutes. Apparently, there is a strong correlation between test results and maximal oxygen uptake. Better for runners as it utilizes running economy and technique.
Anaerobic Fitness: May measure power and capacity. Anaerobic power tests are affected by the subject’s pain tolerance and motivation. Anaerobic capacity is affected by phosphocreatine and lactate utilization properties of the muscles.
The Wingate anaerobic test:
A bicycle ergometer test that measures anaerobic capacity. 5-10 minutes of a low-power warm-up followed by 30s of pedaling. Completed using maximal power and a standardized load. Should be completed in the afternoon or evening during peak power times.
Measurable quantities:
MART Test (maximal anaerobic running test):
Used to test properties related to endurance and speed.
RAST Test (running based anaerobic sprint test):
Similar to the Wingate test. Used in ball sports to measure lactic acid tolerance levels. Involves running 35m, six times, as fast as possible.
Mobility and body control:
Body control and agility:
Functional Movement Screen (FMS – Gray Cook):
Muscular strength:
Surface EMGs can measure the following:
Measuring recovery:
Objective tools for monitoring recovery:
Subjective tools for monitoring recovery:
Factors affecting recovery:
Aspects of Physical Performance
1. Endurance: The ability of the respiratory and circulatory system to acquire, process, and deliver oxygen to tissues.
2. Muscular Endurance: The ability of the body (specifically the muscles) to process, store, and utilize energy.
3. Muscular Strength: The ability of the muscle or muscle group to produce force.
4. Mobility: The maximal range of motion (ROM) of joints.
5. Muscular Power: The ability of the muscle or muscle group to produce maximal force as quickly as possible.
6. Speed: The ability to perform a recurring action as quickly as possible.
7. Coordination: The ability to combine several actions into fluid and continuous movement.
8. Agility: The ability to minimize the transition time between two actions.
9. Balance: The ability to control changes in body position in relation to gravity.
10. Accuracy: The ability to control movement of varying intensity and direction.
Endurance Exercise and Cardiovascular Fitness
Definition: The maximum amount of oxygen you can utilize, an amount called VO2 max (maximal oxygen consumption, maximal oxygen uptake, peak oxygen uptake, or maximal aerobic capacity).
How to do it: Minimum effective dose (MED) for maintenance is 5 x 4-minute high-intensity rounds at 87-97% of your maximum heart rate, with approximately 4 minutes of rest or low activity after each round.
Depends on the performance of the respiratory and cardiovascular systems, as well as the energy management in the muscles, i.e. their ability to convert fat and carbohydrates into energy. This is determined by the number of mitochondria, the number of capillaries in the muscles as well as various metabolic pathways (glycolysis, Krebs cycle, and oxidative phosphorylation).
The recommendation is 2 hours and 30 minutes per week. Walking, cycling, swimming, hiking, and even heavy house and yard work. Running, cross country skiing, fast cycling, or ball games will push the intensity to create improvements. Even aerobics, dance, and cross-training classes.
Endurance exercise can be broken down into basic aerobic endurance, tempo endurance, maximal endurance, and speed endurance. It can also be divided into aerobic and anaerobic exercise. The threshold between basic aerobic and tempo is the aerobic threshold. Anaerobic energy production increases with the level of physical effort.
Basic principles of endurance training:
Strength training increases the effectiveness of endurance exercise and improves performance.
Perform restorative exercises and avoid overtraining.
Heart Rate Zones and Lactate Levels for Endurance Training
Zone 1/Basic Endurance 1:
Zone 2/Basic Endurance 2:
Zone 3/Tempo Endurance 1:
Zone 4/Tempo Endurance 2:
Zone 5/Maximal Endurance:
Beyond Zone 5:
If your endurance fitness is good but you get fatigued as soon as your muscles start producing lactic acid, you should add intervals in heart rate zone 4.
If intervals pose no problem but you get fatigued during prolonged exercises performed at a steady pace, you should add exercises in heart rate zone 2 and intervals in zone 3.
If you can’t sprint to the finish at the end of a 5km run, you should add intervals in heart rate zone 5 (maximal endurance).
If your body is slow to recover, add exercises in heart rate zone 1.
Common pitfalls of endurance training are training at the same intensity level and heart rate zone over and over, training at the same pace, and training too hard on lighter training days or vice versa.
The structural benefits of endurance exercise include increases in heart volume and muscular strength, lung volume, number of mitochondria and microvasculature. Functional benefits are lower blood pressure at rest, lower resting HR, increased heart stroke volume and cardiac output, and improved oxygen uptake. Also, a positive impact on anxiety and depression, balancing stress and the treatment and prevention of numerous chronic illnesses.
Disadvantages from excessive endurance exercise include cardiac remodeling and increased arrhythmia. Also, more likely to have repetitive strain injuries and impaired muscle mass and strength.
Maximum stamina
Definition: The ability to move at low to moderate intensity for 90 minutes or longer. Around the 90-minute mark, your muscle and liver glycogen stores run out, and your body has to burn fat for fuel.
How to do it: Once or twice per month, do something like a backpacking trip, long bike ride, Bikram yoga session, or anything else that combines endurance, mental focus, and low-to-moderate-intensity physical activity. Try to do it in a fasted state or with ketone, amino acids, and electrolytes.
Maximum Mitochondrial Density:
Definition: Mitochondria are responsible for producing ATP. Mitochondrial biogenesis is the creation of new mitochondria, and increasing mitochondrial density means packing the maximum number of mitochondria into your muscles so you can metabolize more fat and glucose.
How to do it: 4 x 30s all out sprints activates mitochondrial biogenesis in the skeletal muscle of humans. 3 sets of 5 x 4s treadmill sprints with 20s rest between sprints 3 times per week has the same effect.
Summary: All you need is short, intense sprints. Tabata sets will cover most of your mitochondrial bases, but if you have time to spare after your strength or endurance workouts, perform a few brief, intense sets of sprints.
Strength Training
Physical strength is determined by two factors: the cross-sectional area of a muscle as well as muscle fiber volume and their contractile intensity. Force generation hinges on the ability of the nervous system to command, recruit, and organize the muscle fibers more efficiently. The strength of connective tissue, such as tendons and fibrous tissues, also affect the ability of the muscles to generate force. Force generation also varies with cell type distribution, sex, age, hormonal balance, nervous system function, general health, and nutritional status.
Key factors:
Maximal strength: 1-5 repetitions reaching 85-100% of the 1RM. 3-5 x 3 sets. Rest for 3-5 minutes between sets. 5-10s TUT.
Speed strength and explosive strength: Sub maximal (40-80% 1RM) loads in several sets. 7-9 x 3. Rest for 1-3 minutes between sets. 5-10s TUT.
Ideal Strength-to-Muscle-Mass Ratio
Definition: Wiry, explosive muscle that is functional and strong.
How to do it: Super-slow lifting protocol (30-60s reps and relatively high weights)
Optimized fat burning, metabolic efficiency, and blood sugar control
Definition: Maximizing your body’s ability to generate ketones and burn fatty acids for fuel while avoiding frequent fluctuations in blood sugar.
How to do it:
Summary: Start each day with 10-30 minutes of light, fasted-state activity (yoga, walking the dog, yard work), take at least one cold shower per day, visit the sauna at least once per week, consume only nutrient dense carbohydrates like sweet potatoes and dark, leafy greens, and be as active as possible all day long. You can even control blood glucose fluctuations with a simple 15-minute walk after the day’s main meal.
Hypertrophy: 8-12 (65-85% of 1RM). Most effective is 3-5 x 8-10. Rest for 60-90s. 30-60s TUT.
Strength endurance: Sets of 12 with sub-maximal loads (20-70%). 3 x 15-20. Rest for 30-60s. More than 60s TUT.
Varying TUT duration can impact different energy systems (ATP, creatine phosphate, and anaerobic glycolysis). A set of slower repetitions of longer TUT performed to exhaustion is more effective for hypertrophy than faster reps.
Maximum Muscular Endurance and Aerobic Capacity
Definition: Your maximal muscular endurance is the amount of work your muscles can endure, and your maximum aerobic capacity is the maximum amount of time you can “do battle” while keeping your force output high.
How to do it: Tabata sets – 4 minutes of going all out for 20s, resting for 10s, and repeating. 2 x per week with full body bodyweight exercises.
Recovery: The supercompensation theory
Training consumes common resources, biochemical cascades, energy reserves, and the nervous system. Therefore, training represents a catabolic activity.
The body needs rest, hydration, and nutrition to bounce back from the catabolic state. If recovery is optimal, the body becomes stronger and more powerful by the time of the next workout. If it is too short, the next workout will consume even more of the body’s resources, leading to overtraining. If the rest period is too long, the progress will be lost.
Training Periodization
Train with weights that are light enough for proper form. Add 2.5kg of weight each session (squat and deadlift); for other exercises add weight every other session. Add weight until you can no longer complete 3 x 5. Reduce the set weights to what they were 2-3 weeks ago and begin again from there.
Strength training strengthens bones, increases muscle mass, helps weight management, improves muscular endurance, reduces the occurrence of musculoskeletal ailments, and slows down sarcopenia.
Disadvantages include injury if improper form is carried out. Strains, muscle cramps, joint pains, ruptured muscles or bone fractures.
Isometric training:
Eccentric quasi-isometric training:
Super-slow repetitions:
Super-slow eccentric repetitions:
Seven-minute workout (30s with 10s rest between):
Negative repetitions:
HIIT
85-95% of maximum heart rate completed in interval form. Rest phase is usually 60-70% of maximum heart rate. By varying the action phase from 10s-4 minutes, it is possible to develop the body’s various energy systems. However, there doesn’t seem to be a link between the length of the rest phase and the biochemical effects of the exercise on muscle cells (lactate, ATP, creatine phosphate, and H+). Meaning, the benefits of varying rest intervals can be explained by neurological, hormonal, and cardiovascular changes.
HIIT develops the cardiovascular and circulatory systems, maximal oxygen uptake, insulin sensitivity, and sugar metabolism, as well as lactate tolerance. Not to mention fat burning. It has been shown to increase mitochondria in muscle cells and the volume of oxidative enzymes in the muscles.
Tabata:
The Gibala Method: 3min warm-up, 60s exercise, 75s rest, repeated 8-12 times.
Sprint Interval Training: May significantly increase levels of myokinase and creatine phosphokinase enzymes in muscle cells as well as boost the activity of glycolytic enzymes and mitochondrial enzyme activity. Meaning it improves aerobic and anaerobic energy expenditure of muscle cells. It may also increase cross-sectional muscle area and to change muscle cell distribution to favor fast IIA cells. It has also been shown to increase GH and testosterone.
HIRT: Resistance training HIIT. Shorter recovery periods are better at producing GH and improving muscular endurance.
Sample:
1. Superset 1 (8-10 min without breaks)
2. S2 (8-10 minutes without breaks)
S3
Gymnastics
The goal is to improve physical strength, coordination, balance, agility, muscular endurance, and flexibility. Excellent for developing children.
Easy:
Medium:
Difficult:
Kettlebell Training
Strength, speed, balance, and endurance. Also improve endurance and maximal oxygen uptake.
Easy:
Medium:
Difficult:
Sample (circuit training – one exercise to the next with a 30-60s break):
Warm up for 5-10 minutes (slingshot and halo, light jogging, indoor rowing, or burpees)
Actual training:
Compact and explosive muscle beats out pure muscle mass for slowing aging. The healthiest muscles are found on a wiry physique of modest size, capable of exerting a lot of force over a short period. The minimum effective dose of strength training would be two specific workouts per week. The first workout is a super-slow lifting protocol (similar to Dr. Doug McGuff in Body by Science). For 12-20 minutes, perform multi-joint exercises with relatively heavy weights, doing each rep over 30-60s.
Performing reps slowly has low injury-producing potential. Super-slow resistance training to muscular fatigue results in the same type of cardiovascular adaptations caused by a long run (lactic acid buffering, increased mitochondrial density, and better blood pressure).
The second workout is a high-intensity bodyweight circuit designed by researchers to maintain strength and muscle in as little time as possible. Each exercise is to be performed for 30s, with 10s rest between exercises.
Except for wall sits, perform as explosive as possible:
Natural Movement
Parkour training program:
Deep bodyweight squat
Hanging on a bar (passive)
Wall support
Walking on all fours
Jogging, sprints, and jumps
Bodyweight:
Mobility:
Optimal mobility is crucial for good posture and prevention of incorrect positions during exercise.
Dynamic, short stretches as well as MET (muscle energy technique) and PNF (proprioceptive neuromuscular facilitation stretching). MET is suitable for treatment of painful muscle tension caused by oxygen deficiency. Yoga, Pilates, fustra, tai chi, and mobility training can help overall mobility and flexibility.
Dynamic stretching program:
Exercise can directly improve our immune system, by increasing immune cell production, and also indirectly improve it by contributing to fixing metabolic syndrome.
Regular exercise stimulates the body’s defense mechanisms and strengthens immunity by activating nuclear factor erythroid 2–related factor 2 (NRF2). NRF2 activation is how our body activates our antioxidant response element (ARE) increasing the production of numerous antioxidants and antioxidant enzymes throughout the body. In fact, this is how hormesis works, by activating NRF2 and then upregulating our body’s own antioxidant defense systems. NRF2 also promotes lymph and blood circulation. Exercise improves arterial function, which protects against the development of atherosclerosis and has anti-inflammatory benefits. Exercise also improves gut microbiome diversity, where around 70% of our immune system resides. Regular exercise enhances immuno-surveillance, lowers basal inflammation, which may protect against cytokine storms, and benefits other chronic health conditions.
Skeletal muscle produces muscle cell cytokines called myokines that exert hormonal, immunomodulating, regenerative and anti-inflammatory effects. It’s been found that skeletal muscle can antagonize antiviral CD8+ T cell exhaustion by protecting T cell proliferation from inflammation. Muscle tissue is also in communication with other organs of the body, such as the bone, pancreas, thymus, lungs, brain, and intestines. Myokines and physical activity can alleviate immuno-senescence and slow it down.
Ways That Exercise Benefits the Immune System
What’s the Optimal Dose of Exercise?
Exercise bouts less than 60 minutes increase the circulation of anti-inflammatory cytokines, immunoglobulins, neutrophils and others that all have an important role in fueling immunity. 30 minutes of walking has been shown to raise natural killer cells, lymphocytes, monocytes and neutrophils. It appears that moderate intensity exercise lasting less than 60 minutes is protective against infections, whereas, prolonged strenuous exercise causes a transient immunosuppression.
Suggested exercise dose, duration and frequency to boost the immune system:
This isn’t to say that you should never perform intense prolonged exercise of 60 minutes or more, it simply increases your risk of infection, which can obviously hinder training or performance during events. It’s a risk vs. benefit balance, i.e., you may increase your conditioning and/or muscle growth with heavy exertion exercise of 60 minutes or longer but you may also increase the risk of infection. It’s important to note that most of the studies that look at heavy exertion increasing the risk of infections have to deal with running, cycling or swimming. Thus, whether this applies to those who are lifting weights intensely for 60 minutes or longer is debatable but at some point, the longer you lift heavy, the greater at risk you will be for getting respiratory infections.
A potential strategy to offset the increased risk of infections after intense prolonged exercise:
Acute as well as chronic changes in immunity caused by exercise are now also described as important for mediating the reduced risk of chronic disease like cardiovascular disease and cancer. Exercise improves arterial function, which protects against the development of atherosclerosis and acts as an anti-inflammatory.
During exercise, natural killer cell activity increases but it drops to a minimum 2 hours later and returns to pre-exercise levels in 24 hours.
Protein powder enriched with green tea and blueberries may protect athletes against viral infections following prolonged strenuous exercise. After ingestion of the protein and plant polyphenols, athletes’ blood had improved antiviral properties. The immunosuppression after exercise may be due to a shift away from the Th1 immune response towards the Th2 response. Th1 immune responses are inflammatory, which are critical for early antiviral activity during infections. Certain compounds that can recover the Th1-type immune response after exercise may improve antiviral properties.
Chronic stress is one of the major contributors to an imbalanced immune system and predisposition to diseases. Patients with viral infections show elevated levels of cortisol. Stress hormones and pro-inflammatory cytokines do not reach high levels during moderate exercise. Prolonged endurance athletes are also more likely to get sick than power athletes because strength sports tend to be shorter in duration and less stressful.
Sedentary people with no physical activity bear a normal risk for URTIs whereas it’s 40-50% lower in those who exercise moderately. Individuals who exercise 5 or more times a week experience 43% fewer days of URTI illness. Yet again, heavy exertion may lead to a 2-6-fold increased risk of sickness (J-shaped curve).
The general consensus is that short bouts of moderate to intense exercise, up to 60 minutes are beneficial for increasing immune defense whereas it will likely decrease when the duration exceeds 60 minutes.
Muscle Mass and Immuno-senescence
After the age of 40, lean mass and strength goes down at a rate of about 2% per decade and fat mass increases approximately 7.5% per decade. However, the greatest changes occur after the age of 50, where more than 15% strength loss occurs per decade. This sarcopenic deterioration makes it easier to gain weight, promotes poor metabolic health, leads to insulin resistance, increases damage from falls and all-cause mortality. Having more muscle mass, on the other hand, has the opposite effect i.e., better insulin sensitivity and glucose tolerance, stronger bones, and increased longevity.
Sarcopenia and decreased fitness are primarily attributed to a sedentary lifestyle, not necessarily aging.
Regardless of age, physical inactivity, alcohol and insulin resistance decrease muscle protein synthesis (MPS) which is the process of keeping and building muscle tissue. As rates of MPS decrease, the body begins to slowly lose functional lean mass, which will eventually lead to worse metabolic health and less myokines. Conversely, it is well demonstrated that resistance training enhances protein synthesis in both young and older people. Even a single bout of resistance training can increase MPS by 2-3 times, which may be enhanced further with a protein-rich diet.
Exercise promotes autophagy and the growth of new mitochondria, called mitochondrial biogenesis. Resistance training has been shown to activate autophagy and reduce apoptosis of muscle cells. Some aspects of time-restricted eating can also be an effective way to relieve the burden of dysfunctional mitochondria. However, excessive overtraining or too much fasting can lead to too much autophagy activation and result in muscle atrophy.
Here is the course of events, starting with inactivity and ending with immuno-senescence:
Resistance Training and Muscle Growth
With age, you see a decline in type IIb muscle fibers also known as fast twitch muscle fibers, which are trained primarily with high intensity resistance training. This is probably because of underuse because people tend to engage in less of this kind of explosive power and strength activities.
The best exercises for increasing muscle growth and strength are full-body compound exercises like squats, deadlifts, bench press, overhead press, barbell rows, pull-ups, push-ups, dips, walking lunges, sprints, kettlebell swings and farmer’s carries. Both weights and calisthenics can provide a sufficient stimulus because the body can’t tell the difference where it’s coming from.
Blood flow restriction (BFR) training or occlusion training is a form of exercise that applies occlusion cuffs around the muscles that are being trained. This restricts blood flow to the target region, creating partial blood flow restriction. BFR combined with low load resistance training enhances muscle hypertrophy and strength. BFR may also result in small strength gains during low-intensity aerobic training. Best of all, BRF alone can attenuate muscle atrophy, especially amongst older people who are less able to lift heavy weights.
Protein Intake and Muscle Growth
Muscle growth results from the positive balance between muscle protein breakdown (catabolism) and muscle protein synthesis (anabolism). Things that encourage catabolism are exercise, fasting, calorie restriction, protein restriction, sarcopenia, hyperglycemia, and physical inactivity. Anabolic catalysts include resistance training, sufficient calories, sleep and dietary protein.
Adequate protein intake prevents muscle loss or sarcopenia, frailty, and dependence on caretaking later in life. Higher protein intakes during dieting promotes weight loss, helps to maintain more muscle and keeps the metabolic rate up.
You want to eat whole food proteins like eggs with the yolk, salmon, mackerel, beef, chicken, organ meats, red meat, etc. Plant based alternatives are legumes, beans, quinoa, nuts and seeds but to make them complete you’d have to combine several protein sources and their leucine content, which is required for muscle protein synthesis, tends to be lower.
Exercise Recovery
Here are signs of over-training and/or under-recovery:
Recommended supplements pre-work out
Recommended supplements post-work out
It has been found that antioxidant supplements, NSAIDS, and cryotherapy after working out reduces inflammation and exercise-induced oxidative stress, which can slow down or completely negate the adaptive signal needed for muscle growth.
Antioxidant supplementation before exercise has been shown to interfere with mitochondrial biogenesis, which is a key adaptation to endurance performance capacity. Multiple studies have also found antioxidant supplements to impair anabolic signaling and muscle hypertrophy. However, it does not seem to affect muscle strength. Vitamin C doesn’t appear to benefit exercise performance and it may impair exercise performance at doses above 1000 mg/day.
Overall, having a higher HRV means you are more recovered, less stressed, and parasympathetic dominant. Decreased HRV has been shown to be a predictor of mortality after myocardial infarction, cancer, and sudden cardiac death. Lower HRV is also associated with heart failure, diabetic neuropathy, and liver cirrhosis. In fact, the risk of dying after a heart attack is more than 5-fold higher for those with low HRV vs. high HRV.
If your HRV is low, it is not the smartest idea to exercise hard or impose other forms of hormetic stressors, like the sauna or cold, as there is an increase in sympathetic drive during and potentially after the acute stressful event. For example, sauna sessions may lower HRV but they have also been shown to reduce arrhythmias and improve HRV in patients with chronic heart failure. Sauna sessions can have cardiovascular benefits such as lowering vascular resistance and other studies have found that sauna sessions improve HRV upon recovery from the session. Thus, sauna sessions may be good or bad on HRV, depending on the person.
There is a clear association between an elevation of pro-inflammatory IL-6, higher C-reactive protein, and decreased HRV. Usually, an elevated heart rate and body temperature is a sign of an active infection.
Here are things that lower heart rate variability (HRV) and impair recovery:
Here are the things that increase heart rate variability (HRV):
Overtraining:
Hypotheses for the cause of overtraining:
Factors that promote the onset of overtraining syndrome:
Laboratory tests:
Can You Build Muscle and Lose Fat at the Same Time?
To lose fat you have to be at an energy deficit i.e. burn more energy than you consume.
To build muscle you have to be at an energy surplus i.e. consume more energy than you burn.
Calories aren’t just calories because they can be partitioned differently according to the macronutrient ratios, quality of nutrients, hormone levels, training status, and overall energetic demands on the body.
If your workouts are stimulating the muscles enough, and if you follow it up with adequate muscle protein synthesis by consuming enough protein, then the rest of what you need can be derived from stored body fat. Likewise, you can gain fat and lose muscle at the same time by doing a lot of catabolic exercise like chronic cardio for hours and overconsuming daily calories with very little protein.
The adipose tissue consists of stored triglycerides, which is an ester comprising of three fatty acid molecule chains and a glycerol backbone that holds them together. This single fat particle can cover most of the body’s metabolic needs in at least the short term. Fat is fuel that most tissues and muscle can use.
Lactate is the byproduct of glucose metabolism and it’s been shown to contribute up to 18% of skeletal muscle glycogen synthesis after high-intensity exercise. Basically, during high-intensity workouts, you’re producing a lot of lactic acid by burning off your muscle glycogen. To eliminate the burn effect and restore the glycogen you lost, the body uses some amounts of that lactate for muscle glycogen resynthesis.
There are certain times the body needs more fuel and amino acids than at others. For instance:
In the case of intermittent fasting, you would inevitably see a much bigger lean muscle gain if you were to consume most of your calories after a resistance training workout. The dominos will all be set in line – the mechano-overload from exercise, depleted glycogen stores, activated mTOR, and nervous system fatigue – everything is much favorable for building muscle as long as you stimulate MPS and bring in the building blocks.
Intermittent fasting and time-restricted feeding are such powerful tools for building muscle and burning fat at the same time.
Losing Muscle While Fasting
Growth hormone increases exponentially by up to 2000-3000% at the 24-hour mark.
Another hormone that’s going to help you build muscle is testosterone.
(1) Gluconeogenesis While Fasting
The reason you may trigger gluconeogenesis is that you don’t have access to other fuel sources, like fat. Your body isn’t keto-adapted to burning ketones yet and the next best thing it can think of is protein.
(2) Autophagy and Muscle Loss
The second reason why you may lose muscle while fasting is the inhibition of autophagy. Studies have found that autophagy is needed for maintaining muscle mass.
Even as little as 50 calories or 2-3 grams of leucine will stop autophagy and shift you into a fed state. It’s going to be better for fat loss, for muscle sparing and for longevity, to avoid all calories during your fasting window.
There are several possible mechanisms by which a ketogenic diet preserves muscle mass and prevents protein catabolism.
Can Fasting Make You Build Muscle
Studies have found that fasting lowers the expression of mTOR and IGF-1, which are both needed for cellular growth by increasing one of their inhibiting proteins called IGFBP1.
TOR has quite a detrimental role in anabolism. Inhibiting mTOR blocks the anabolic effects of resistance training and prevents muscle growth. mTOR is clearly anabolic but also anti-catabolic. It’s going to protect the body against the harmful effects of cortisol and glucocorticoids on muscle tissue.
The rationale of trying to build muscle and strength with intermittent fasting isn’t oriented towards maximizing muscle growth or performance. It’s about prioritizing longevity and not over-stimulating the anabolic effects of mTOR all the time.
When you’re doing resistance training, then you’re inducing damage to the muscle cells and tissues. If you consume adequate protein after the workout, you’ll be able to heal that damage and hopefully result in sarcoplasmic hypertrophy. However, when working out fasted you have limited amino acid availability and thus are subject to increased muscle damage. That may not be ideal for someone trying to build more muscle because they may end up with a NET negative muscle homeostasis.
The amounts of protein you can absorb in one sitting is arbitrary for maintaining lean tissue but it’s probably not optimal for positive NET growth. That’s why having some amino acids circulating the bloodstream during the workout will not only minimize the muscular damage but will also promote additional muscle protein synthesis after training.
However, there are still some advantages to working out fasted:
To maximize the autophagic benefits of fasting, you’d want to fast for as long as possible every day. In most cases, that would entail about a 20-hour fasted window.
For optimal muscle growth, you’d want to have a smaller number of amino acids and protein in your system before working out.
For better body composition and nutrient partitioning, you’d benefit more from backloading most of your calories into the post-workout scenario where your body prioritizes recovery.
Here’s what the Targeted Intermittent Fasting Protocol looks like:
Post-Workout Nutrition While Fasting
Eating immediately afterwards isn’t ideal because you may be still under the influence of cortisol and digestive stress, which can promote gut issues and fat gain. The sweet spot for muscle protein synthesis and avoiding catabolism seems to be between 60-195 minutes after training but not before 60 minutes.
Protein shakes would have the most effect either immediately before or intra-workout ala targeted intermittent fasting. If you wait for 2 hours and eat, then it’d be better to get your amino acids from real food but if you don’t have access to those conditions, then the shake is a great alternative.
When taking any fitness supplements, you have to be wary of their ingredients and content. You definitely want to avoid artificial sweeteners like sucralose, saccharin, fructose, and aspartame because they’re linked to insulin resistance and other diseases. They’re still going to spike insulin and even disrupt the microbiome by promoting the proliferation of certain gut buts that can extract more calories from the food you eat.
In general, workout somewhere between the 16–20-hour mark of fasting and wait at least 60-120 minutes before eating anything. The fear of missing out on this so-called “anabolic window” wherein you’ll start building exponentially more muscle is futile.
Re-feeding after fasting, especially on carbohydrates, raises the thermic effect of food, which produces excess body heat and can lead to a positive result in body composition.
Part of the reason why cholesterol helps with muscle growth may have to do with the anti-oxidant properties of cholesterol and the repair mechanisms it triggers. Cholesterol improves membrane stability of cells which enhances their resiliency against muscle damage during exercise. This also controls inflammation during recovery. Cholesterol supports mTOR and IGF-1 signaling by helping with the formation of signaling pathways.