The Human Operating Manual

Evolution & Genetics

Evolution & Genetics Sapolsky: Sexual selection and reproductive fitness Kinship and degree of relatedness Reciprocal altruism. Must be smart enough to remember each other and their interactions. Must be long lived. Cooperation, cheating, detecting cheating. Caveat: bacteria still do tit for tat and reciprocal interaction.  Game theory. Prisoner’s dilemma Optimizing genetics for the given environment. …

LUCA & the Energy Bubbles

LUCA & the Energy Bubbles Potential hypotheses for life: thermal vents, spark (lightening), panspermia, etc. What life means: Encapsulated potential for energy that is used for greater dispersal Sponges and mat grazers (Mike Paulin research). Fear vs gain (glutamate and calcium channels) Bayesian Brain Theory, The Free Energy Principle https://www.nature.com/articles/nrn2787 https://medium.com/@solopchuk/intuitions-on-predictive-coding-and-the-free-energy-principle-3fc5bcedc754 Our senses, epithelial cells, …

Energy Factories

Energy Factories Mitochondria http://thehumanoperatingmanual.com/mitochondria-and-the-future-of-medicine-the-key-to-understanding-disease-chronic-illness-aging-and-life-itself/ Mineral Fix notes Minerals Driving Energy Production In total, there are up to 22 vitamins and minerals that support mitochondrial enzymes and are needed for energy production. Minerals also help to activate antioxidant enzymes that protect the mitochondria from oxidative stress. Deficiencies in these minerals can lead to a reduction in …

Emergence & Complexity

Emergence & Complexity https://quantumgravityresearch.org/emergence-theory-overview/ https://en.wikipedia.org/wiki/Free_energy_principlehttps://en.wikipedia.org/wiki/Integrated_information_theoryhttps:// www.frontiersin.org/articles/10.3389/fpsyg.2020.01041/fullhttps://pubmed.ncbi.nlm.nih.gov/29729890/ https://www.sciencedirect.com/science/article/abs/pii/S027322972100054X

Entropy

Entropy https://pubmed.ncbi.nlm.nih.gov/34385400/ Connection between the universal demonstration of entropy and our micro example. Our role as an entropy accelerator rather than a resistor. Complexity theory, feedback loops, Jeremy England theory, mitochondrial synergy.  Once we have an averaged energy systems model to detect dysfunction/metabolic leakage, we should be able to use computational neuroscience to replicate and …

The Big Bang

The Big Bang Deep History Notes Big bang (13.7bya)->First galaxies (10bya)->Solar system (4.6bya)->Molten earth (4.5bya)->Earth cools (4.2bya)->Life (~3.8bya) Water provided a medium for chemical compounds to dissolve and be reconfigured as other compounds. Water + heat + carbon. The compounds carbon create are highly stable and don’t readily come apart in water unless the temperature …

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